생물학적 소스
chicken
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
human, rat
제조업체/상표
Genway 15-288-22823
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... BAT3(7917)
일반 설명
BAT3 is a gene from major histocompatibility complex. In humans, it is localized in the class III region of the human major histocompatibility complex on chromosome 6. It consists of an ubiquitin homology region at the N-terminal end, short tracts of polyproline and polyglycine, a zinc finger-like domain and a nuclear localization signal (NLS) at the C- terminus end. It is a member of BAG family of proteins. The major responsibility of BAG proteins is to negatively control the chaperone function of the Hsp70 family.
면역원
Immunogen Sequence: GI # 18375632, sequence 2-250
Recombinant HLA-B associated transcript-3 isoform b
애플리케이션
Anti-BAT3 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
생화학적/생리학적 작용
Large proline-rich protein BAT3 is a protein encoded by the BAT3 gene in humans. It is very rich in proline and includes short tracts of polyproline, polyglycine and charged amino acids. BAT3 is similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin and synapsin. It has distinct functions in the cytosol and in the nucleus. It is also associated with controlling of apoptosis and regulating heat shock protein (HSP) 70 activity.
물리적 형태
Solution in phosphate buffered saline containing 0.02% sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
S T Manchen et al.
Biochemical and biophysical research communications, 287(5), 1075-1082 (2001-10-06)
Human Scythe (also known as BAT3) has been implicated in the control of apoptosis and regulating heat shock protein (HSP) 70 activity. We have attempted to further characterize the role of human Scythe in HeLa cells by studying the cellular
Manu Rangachari et al.
Nature medicine, 18(9), 1394-1400 (2012-08-07)
T cell immunoglobulin and mucin domain–containing 3 (Tim-3) is an inhibitory receptor that is expressed on exhausted T cells during infection with HIV-1 and hepatitis C virus. By contrast, Tim-3 expression and function are defective in multiple human autoimmune diseases.
Toru Sasaki et al.
Genes & development, 21(7), 848-861 (2007-04-04)
In response to DNA damage, p53 undergoes post-translational modifications (including acetylation) that are critical for its transcriptional activity. However, the mechanism by which p53 acetylation is regulated is still unclear. Here, we describe an essential role for HLA-B-associated transcript 3
Nadine Kämper et al.
PloS one, 7(4), e35972-e35972 (2012-05-05)
The human lymphocyte antigen (HLA) encoded BAT3/BAG6 recently attracted interest as a regulator of protein targeting and degradation, a function that could be exerted in the cytosol and in the nucleus. The BAT3 gene was described to consist of 25
J Banerji et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(6), 2374-2378 (1990-03-01)
A large number of genes has been identified previously between the class I and class II gene families within the class III region of the human major histocompatibility complex. The complete sequences of two of these genes, BAT2 and BAT3
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