GW21046

Anti-CCR2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-Chemokine (C-C motif) receptor 2 isoform A, Anti-MCP-1 receptor
• MDL number: MFCD01864606
• UNSPSC 코드: 12352203

속성

• 생물학적 소스: chicken
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 종 반응성: human
• 제조업체/상표: Genway 15-288-21046
• 기술: western blot: suitable
• NCBI 수납 번호: NP_000638.1
• UniProt 수납 번호: O95950
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... CCR2(1231)

설명

일반 설명

CCR2 (chemokine (C-C motif) receptor 2) belongs to the chemokine receptor family, which are small (8-10kDa) G-protein coupled receptors (GPCR). This family is subdivided into four families called CC, CXC, CX3C and XC. CCR2 belongs to the CC family, and has its ligand-binding domain in its exoplasmic N-terminal. Its C-terminal is involved in intracellular signaling. It is constitutively expressed by monocytes, and is found on T-cells, naïve B-cells, NK (natural killer) cells, dendritic cells and basophils.

면역원

Immunogen Sequence: GI # 4502633, sequence 1-45

Recombinant chemokine (C-C motif) receptor 2 isoform A

애플리케이션

Anti-CCR2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
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생화학적/생리학적 작용

C-C chemokine receptor type 2 (CCR2) is an important chemokine for monocyte aggregation and transendothelial monocyte migration. CCR2 plays an important role in extravasation and transmigration of monocytes under inflammatory conditions. It is involved in the growth and invasion of prostate cancer (PCa). CCR2 expression is very important for CCL2-induced proliferation and invasion of PC-3M cells. CCR2 can also act as a promising molecular target for prevention of PCa growth and metastasis.

물리적 형태

Solution in phosphate buffered saline containing 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)