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Merck
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Key Documents

GW21024

Sigma-Aldrich

Anti-ADCY6 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

동의어(들):

Anti-Adenylate cyclase type 6, Anti-KIAA0422

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

chicken

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

종 반응성

human

제조업체/상표

Genway 15-288-21024

기술

western blot: suitable

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... ADCY6(112)

면역원

Immunogen Sequence: GI # 10181096, sequence 1-121
Recombinant adenylate cyclase 6 isoform a

애플리케이션

Anti-ADCY6 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

생화학적/생리학적 작용

Adenylate cyclase type 6 is an enzyme encoded by the ADCY6 gene in humans. It is a critical regulator of metabolic and cardiovascular function. It is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types. It is localized in lipid rafts of COS-7 cells (expressing caveolin-1). Both the C1 and C2 domains of AC6 play a role in targeting AC6 to lipid rafts.

물리적 형태

Solution in phosphate buffered saline containing 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


시험 성적서(COA)

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문서 라이브러리 방문

Gary J Hodges et al.
The Journal of pharmacology and experimental therapeutics, 335(2), 451-457 (2010-08-25)
Adenylyl cyclase (ADCY) is a critical regulator of metabolic and cardiovascular function. We have identified a genetic variant (A674S) in ADCY isoform 6 (ADCY6). Subsequent studies demonstrated that the expression of this ADCY6 variant paralleled an increase in adenylyl cyclase-mediated
Muthusamy Thangavel et al.
Cellular signalling, 21(2), 301-308 (2008-11-15)
Previous data has shown that adenylyl cyclase type 6 (AC6) is expressed principally in lipid rafts or caveolae of cardiac myocytes and other cell types while certain other isoforms of AC are excluded from these microdomains. The mechanism by which

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