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Merck
모든 사진(1)

문서

G8378

Sigma-Aldrich

Guanosine 5′-tetraphosphate tris salt

from Saccharomyces cerevisiae, ~95%

동의어(들):

G-tetra-P

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C10H17N5O17P4
CAS Number:
103213-27-0
Molecular Weight:
603.16
MDL number:
MFCD00058646
UNSPSC 코드:
41106305
PubChem Substance ID:
329799979

생물학적 소스

Saccharomyces cerevisiae

분석

~95%

형태

solid

배송 상태

dry ice

저장 온도

−20°C

SMILES string

NC(CO)(CO)CO.NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H17N5O17P4.C4H11NO3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(29-9)1-28-34(22,23)31-36(26,27)32-35(24,25)30-33(19,20)21;5-4(1-6,2-7)3-8/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H,26,27)(H2,19,20,21)(H3,11,13,14,18);6-8H,1-3,5H2/t3-,5-,6-,9-;/m1./s1

InChI key

ZEHPDAAYQIAYON-GWTDSMLYSA-N

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생화학적/생리학적 작용

Guanosine 5′-tetraphosphate (G-tetra-P) may be used as a substrate to study the specificity and kinetics of polyphosphatases (triphosphate tunnel metalloenzymes (TTMs)) and exopolyphosphatases. Also used as an inhibitor to study the kinetics and mechanism of various guanylate cyclases. Guanosine 5′-tetraphosphate may be used in various studies with adenosine-5′-tetraphosphate.

픽토그램

Health hazard
GHS08

신호어

Warning

유해 및 위험 성명서

H371

Hazard Classifications

STOT SE 2

표적 기관

Eyes,Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Ruchi Jain et al.
The Journal of biological chemistry, 283(45), 31047-31057 (2008-09-11)
Triphosphate tunnel metalloenzymes (TTMs) are a superfamily of phosphotransferases with a distinctive active site located within an eight-stranded beta barrel. The best understood family members are the eukaryal RNA triphosphatases, which catalyze the initial step in mRNA capping. The RNA
Jianmin Fang et al.
The Journal of biological chemistry, 282(44), 32501-32510 (2007-09-11)
We report the cloning, expression, purification, and characterization of the Trypanosoma cruzi exopolyphosphatase (TcPPX). The product of this gene (TcPPX), has 383 amino acids and a molecular mass of 43.1 kDa. TcPPX differs from most exopolyphosphatases in its preference for
T V Kulakovskaya et al.
Biochemistry. Biokhimiia, 62(9), 1051-1052 (1998-02-11)
A cytosolic preparation of Saccharomyces cerevisiae is capable of hydrolyzing adenosine-5'-tetraphosphate and guanosine-5'-tetraphosphate with activities which are 1.5-2 times greater than that with polyP15. The apparent K(m) values for hydrolysis of adenosine-5'-tetraphosphate and guanosine-5'-tetraphosphate are 100 and 80 microM, respectively.
Faylene A Lunn et al.
The Journal of biological chemistry, 283(4), 2010-2020 (2007-11-16)
Cytidine 5'-triphosphate synthase catalyzes the ATP-dependent formation of CTP from UTP using either NH(3) or l-glutamine (Gln) as the source of nitrogen. GTP acts as an allosteric effector promoting Gln hydrolysis but inhibiting Gln-dependent CTP formation at concentrations of >0.15
A Garger et al.
Visual neuroscience, 18(4), 625-632 (2002-02-07)
The second messenger systems involved in the final stages of the phototransduction cascade in Limulus photoreceptors remain unclear. Excised patches of transducing membrane contain cGMP-gated channels, suggesting the involvement of cGMP in the excitation process. To further explore this possibility

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