F8929

Fluconazole

≥98% (HPLC), powder, fungal cytochrome P-450 sterol C-14 α-demethyllation inhibitor

• 동의어(들): 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
• 실험식(Hill 표기법): C₁₃H₁₂F₂N₆O
• CAS Number: 86386-73-4
• Molecular Weight: 306.27
• MDL number: MFCD00274549
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724485
• NACRES: NA.77

속성

• product name: Fluconazole, ≥98% (HPLC), powder
• 분석: ≥98% (HPLC)
• 형태: powder
• solubility: DMSO: 5 mg/mL
• 항생제 활성 스펙트럼: fungi
• 동작 모드: enzyme | inhibits
• 저장 온도: room temp
• SMILES string: FC1=CC(F)=C(C(CN2N=CN=C2)(O)CN3N=CN=C3)C=C1
• InChI: 1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
• InChI key: RFHAOTPXVQNOHP-UHFFFAOYSA-N
• 유전자 정보: human ... CYP1A2(1544)

설명

일반 설명

Fluconazole is used to treat adult neutropenic patients with invasive candidiasis (IC).

애플리케이션

Fluconazole has been used to assess minimum inhibitory concentration (MIC)-fungal assay. It has also been used as a positive control in antifungal assay of plants.

생화학적/생리학적 작용

Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H360D,H362,H412
• 예방조치 성명서: P202 - P260 - P263 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Lact. - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves