생물학적 소스
rabbit
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
종 반응성
human
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3 μg/mL using human kidney, cortex
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... FZD10(11211)
mouse ... Fzd10(93897)
면역원
synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-10, conjugated to KLH. The immunizing peptide has 100% homology with the mouse gene.
애플리케이션
Anti-Frizzled-10 antibody is suitable for immunohistochemistry study (formalin-fixed, paraffin-embedded sections) at a concentration of 3μg/mL using human kidney, cortex.
생화학적/생리학적 작용
Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In humans, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. FZD10, a cell-surface receptor molecules in the Wnt pathway, is expressed during development in embryonic limbs, neural tube, and central nervous system and mediates Wnt signaling. It was reported that FZD10 plays a critical role in the metastasis of synovial sarcoma. Mechanistically, it facilitates the activation of Dvl-Rac1-JNK axis of planar cell polarity (PCP) signaling, with no effect on nuclear β-catenin accumulation and Tcf/Lef reporter activity.
물리적 형태
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
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시험 성적서(COA)
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Yingqun Wang
Molecular cancer therapeutics, 8(8), 2103-2109 (2009-08-13)
The evolutionarily conserved and developmentally important Wnt signaling pathway has traditionally been regarded as a critical player in tumorigenesis through the canonical Wnt/beta-catenin cascade. Nevertheless, accumulating evidence based on recent research has revealed the previously unacknowledged role of noncanonical Wnt/planar
Satoshi Nagayama et al.
Oncogene, 24(41), 6201-6212 (2005-07-12)
Genome-wide expression profiling revealed overexpression of the gene encoding frizzled homologue 10 (FZD 10), a cell-surface receptor for molecules in the Wnt pathway, as a potential contributor to synovial sarcomas (SS). Northern blotting and immunohistochemical staining confirmed that expression levels
Edlaine Linares et al.
Chemical research in toxicology, 37(7), 1129-1138 (2024-06-25)
Peroxymonocarbonate (HCO4-/HOOCO2-) is produced by the reversible reaction of CO2/HCO3- with H2O2 (K = 0.33 M-1, pH 7.0). Although produced in low yields at physiological pHs and H2O2 and CO2/HCO3- concentrations, HCO4- oxidizes most nucleophiles with rate constants 10 to
Sze Chuen Cesar Wong et al.
PloS one, 8(11), e79481-e79481 (2013-11-21)
Frizzled homolog 3 receptor was up-regulated in several gastrointestinal cancers such as esophageal and gastric cancers. Moreover, frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens. In the present study, we investigated the clinical significance of
Koji Ueno et al.
International journal of cancer, 132(8), 1731-1740 (2012-07-27)
Wnt signaling pathways play important roles in tumorigenesis and are initiated by binding of Wnt to various receptors including frizzleds (FZDs). FZDs are one of several families of receptors comprised of FZD/LRP/ROR2/RYK in the Wnt signaling pathway. Expression of some
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