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Merck
모든 사진(1)

문서

F131

Sigma-Aldrich

FPL 64176

≥98% (HPLC), powder

동의어(들):

2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxlic acid methyl ester

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About This Item

실험식(Hill 표기법):
C22H21NO3
CAS Number:
120934-96-5
Molecular Weight:
347.41
MDL number:
MFCD00274043
UNSPSC 코드:
12352200
PubChem Substance ID:
24277836
NACRES:
NA.77

분석

≥98% (HPLC)

형태

powder

저장 조건

desiccated
protect from light

색상

white to beige

solubility

DMSO: >20 mg/mL (Solutions should be freshly prepared.)
H2O: insoluble

저장 온도

2-8°C

SMILES string

COC(=O)c1c(C)[nH]c(C)c1C(=O)c2ccccc2Cc3ccccc3

InChI

1S/C22H21NO3/c1-14-19(20(15(2)23-14)22(25)26-3)21(24)18-12-8-7-11-17(18)13-16-9-5-4-6-10-16/h4-12,23H,13H2,1-3H3

InChI key

MDMWHKZANMNXTF-UHFFFAOYSA-N

유전자 정보

rat ... Cacnb3(25297)

생화학적/생리학적 작용

Potent Ca2+ channel (L-type) activator.

주의사항

Photosensitive

법적 정보

Manufactured and sold with permission from Astra Charnwood.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

Jeffrey J Ross et al.
The Journal of clinical investigation, 116(12), 3139-3149 (2006-11-14)
Smooth muscle formation and function are critical in development and postnatal life. Hence, studies aimed at better understanding SMC differentiation are of great importance. Here, we report that multipotent adult progenitor cells (MAPCs) isolated from rat, murine, porcine, and human
R J Large et al.
American journal of physiology. Cell physiology, 299(5), C1180-C1194 (2010-08-20)
Hyaluronan, a joint lubricant and regulator of synovial fluid content, is secreted by fibroblast-like synoviocytes lining the joint cavity, and secretion is greatly stimulated by Ca(2+)-dependent protein kinase C. This study aimed to define synoviocyte membrane currents and channels that
Zhong Zhang et al.
American journal of physiology. Renal physiology, 299(4), F862-F871 (2010-07-16)
Multiple voltage-gated Ca(2+) channel (Ca(V)) subtypes have been reported to participate in control of the juxtamedullary glomerular arterioles of the kidney. Using the patch-clamp technique, we examined whole cell Ca(V) currents of pericytes that contract descending vasa recta (DVR). The
Y Zhang et al.
Acta physiologica (Oxford, England), 198(2), 143-158 (2009-11-06)
To investigate the effect of increases in extracellular Ca(2+) entry produced by the L-type Ca(2+) channel agonist FPL-64176 (FPL) upon acute atrial arrhythmogenesis in intact Langendorff-perfused mouse hearts and its dependence upon diastolic Ca(2+) release from sarcoplasmic reticular Ca(2+) stores.
Stefan I McDonough et al.
Biophysical journal, 88(1), 211-223 (2004-10-27)
FPL 64176 (FPL) is a nondihydropyridine compound that dramatically increases macroscopic inward current through L-type calcium channels and slows activation and deactivation. To understand the mechanism by which channel behavior is altered, we compared the effects of the drug on
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