생물학적 소스
sheep
결합
unconjugated
항체 형태
fractionated antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
형태
buffered aqueous solution
분자량
antigen 52 kDa
종 반응성
human, mouse
기술
western blot: suitable using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
유전자 정보
human ... FLI1(2313)
mouse ... Fli1(14247)
면역원
GST fusion protein of the N-terminus of Fli-1 corresponding to amino acids 1-239.
애플리케이션
Anti-FLI-1 antibody produced in sheep is suitable for western blotting using whole extracts from mouse erythroleukemia cell lines, DP16-1 and CB7 and human T-cell line.
생화학적/생리학적 작용
Friend leukemia integration 1 transcription factor (FLI1) is a protein that is encoded by the FLI1 gene in humans and is a member of Ets transcription factor family. It is a proto-oncogene and located on human chromosome 11q23-24. FLI1 may be involved in human sarcomas, leukemias and lymphomas. It may play an important role in the posttranscriptional regulation of the Fli-1 transcript. Alteration in the transcriptional activation function of Fli-1 may be responsible for human malignancies. It is a novel ETS transcription factor involved in gene fusions in prostate cancer.
물리적 형태
Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
V N Rao et al.
Oncogene, 8(8), 2167-2173 (1993-08-01)
Three of the ets oncogene superfamily members v-ets, Spi-1/PU.1 and Fli-1, have been shown to be directly involved in retroviral-mediated acute erythroleukemias. The Fli-1 gene was found to be rearranged in 75% of the erythroleukemias induced by Friend murine leukemia
Paula Paulo et al.
Genes, chromosomes & cancer, 51(3), 240-249 (2011-11-15)
To characterize the pattern of ETS rearrangements and to uncover novel ETS fusion genes, we analyzed 200 prostate carcinomas (PCa) with TaqMan low-density arrays (TLDAs), followed by selective analyses with fluorescence in situ hybridization (FISH), RT-PCR, and sequencing. Besides confirming
Steven M Kornblau et al.
Blood, 118(20), 5604-5612 (2011-09-16)
Friend leukemia virus integration 1 (FLI1), an Ets transcription factor family member, is linked to acute myelogenous leukemia (AML) by chromosomal events at the FLI1 locus, but the biologic impact of FLI1 expression on AML is unknown. FLI1 protein expression
V Baud et al.
Genomics, 11(1), 223-224 (1991-09-01)
FLI1 is a common mouse viral integration region in virus-induced leukemias and lymphomas. Using an evolutionarily conserved mouse probe and Southern hybridization to (rodent x human) somatic cell hybrid DNAs, the human homolog of FLI1 has been shown to lie
D D Prasad et al.
Cancer research, 52(20), 5833-5837 (1992-10-15)
Three ets family members, v-ets, spleen focus forming virus proviral integration 1/Pu.1, and Friend leukemia integration 1 (Fli-1), were shown to be involved in retroviral mediated acute leukemias suggesting that ets family members play a crucial role in transformation. Mouse
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