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Merck
모든 사진(1)

주요 문서

E6264

Sigma-Aldrich

[D-Pen2,5, p-Cl-Phe4]-Enkephalin

≥97% (HPLC)

동의어(들):

[pCl-Phe4]-DPDPE

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About This Item

실험식(Hill 표기법):
C30H38ClN5O7S2
CAS Number:
Molecular Weight:
680.24
MDL number:
UNSPSC 코드:
12352200

분석

≥97% (HPLC)

구성

Peptide content, ~70%

저장 온도

−20°C

SMILES string

CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H]1C(O)=O

유전자 정보

human ... OPRD1(4985)
mouse ... OPRD1(18386)
rat ... OPRD1(24613)

Amino Acid Sequence

Tyr-D-Pen-Gly-p-Chloro-Phe-D-Pen [Disulfide Bridge: 2-5]

생화학적/생리학적 작용

Selective agonist at the δ opioid receptor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

E V Varga et al.
Molecular pharmacology, 50(6), 1619-1624 (1996-12-01)
In the present study, we replaced the third extracellular loop of the human delta-opioid receptor with that of the human mu-opioid receptor. A modified polymerase chain reaction overlap extension method was used to achieve the exact splicing in the chimera
F Niroomand et al.
Naunyn-Schmiedeberg's archives of pharmacology, 354(5), 643-649 (1996-11-01)
Although both opioid receptors and endogenous opioids are abundant in cardiac tissues, the signal transduction pathways of opioids in cardiac sarcolemmal membranes have yet to be identified. In highly purified canine cardiac sarcolemmal membranes, binding of the opioid receptor antagonist
R J Knapp et al.
European journal of pharmacology, 291(2), 129-134 (1995-10-15)
2-methyl-4a alpha-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a alpha-octahydro-quinolino[2,3,30g]isoquinoline (TAN-67) is a nonpeptidic delta-opioid receptor agonist. This report describes its receptor binding affinity and agonist potency at human and mouse delta and mu-opioid receptors. The binding affinities of TAN-67 and the cyclic enkephalin analog, (D-Pen2, 4'-Cl-Phe4
Michael J McCarthy et al.
Psychopharmacology, 213(4), 735-744 (2010-10-14)
The synthesis and release of met-enkephalin and β-endorphin, endogenous ligands for δ-opioid peptide receptors (DOPrs), are altered following nicotine administration and may play a role in nicotine addiction. To investigate the consequences of altered opioidergic activity on DOPr expression, coupling
D C Brown et al.
American journal of veterinary research, 62(4), 496-499 (2001-05-01)
To measure oxytocin concentrations in blood and CSF following central administration of opioid agonists in dogs. 5 male dogs. In a crossover design, CSF and blood were collected immediately before and 15 and 30 minutes after cisternal administration of D-Ala2

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