E4154

Anti-EMMPRIN antibody produced in goat

affinity isolated antibody, lyophilized powder

• 동의어(들): Anti-CD147, Anti-Extracellular Matrix Metalloproteinase Inducer
• MDL number: MFCD02262857
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: goat
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: lyophilized powder
• 종 반응성: mouse
• 기술: indirect ELISA: 0.5-1.0 μg/mL; western blot: 0.1-0.2 μg/mL
• UniProt 수납 번호: P18572
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Bsg(12215)

설명

일반 설명

Extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein encoded by the BSG gene in humans. It is also known as Basigin (BSG). It is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. Expression of CD147 is significantly higher in ectopic endometrial tissues in patients with endometriosis compared to normal endometrial tissues.

면역원

purified recombinant mouse extracellular matrix metalloproteinase inducer extracellular domain (amino acids 22-209), expressed in NSO cells.

애플리케이션

Anti-EMMPRIN antibody produced in goat is suitable for western blotting at a concentration of 0.1-0.2μg/mL and indirect ELISA at a concentration of 0.5-1.0μg/mL.

생화학적/생리학적 작용

CD147 functions as an extracellular matrix metalloproteinase inducer, regulates lymphocyte responsiveness, monocarboxylate transporter expression and spermatogenesis. It interacts with cyclophilin family and acts as a signaling receptor to extracellular cyclophilins A and B. EMMPRIN expression in epithelial ovarian cancers (EOC) is higher than in benign ovarian tumors and normal ovaries. It is associated with the pathogenesis of acute coronary syndrome (ACS) and may act as a biomarker for ACS. EMMPRIN plays important roles in tumor progression and sunitinib resistance in renal cell carcinoma (RCC). It could act as a novel target for the treatment of RCC.

물리적 형태

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)