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주요 문서

COO/COA

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D8065

Dephostatin

Name: Dephostatin
Brand: SIGMA

>98% (HPLC), solid

동의어(들):

1,4-Dihydroxy-N-methyl-N-nitrosoaniline, 2-(Methylnitrosoamino)-1,4-benzenediol, 2-(N-methyl-N-nitroso)hydroquinone

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About This Item

실험식(Hill 표기법):

C₇H₈N₂O₃

CAS Number:

151606-30-3

Molecular Weight:

168.15

MDL number:

MFCD00467665

UNSPSC 코드:

12352200

PubChem Substance ID:

24278389

분석

>98% (HPLC)

형태

solid

색상

light yellow

solubility

DMSO: soluble 22 mg/mL
H₂O: insoluble

배송 상태

wet ice

저장 온도

−20°C

SMILES string

CN(N=O)c1cc(O)ccc1O

유전자 정보

human ... PTPRCAP(5790)

생화학적/생리학적 작용

CD45-associated protein tyrosine phosphatase inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

Antidiabetic effect of a nitrosamine-free dephostatin analogue, methoxime-3,4-dephostatin, in db/db mice.

A Hiroki et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 56(4), 179-185 (2002-07-12)

Et-3,4-dephostatin, a protein-tyrosine phosphatase (PTPase) inhibitor, potentiates insulin-dependent signal transduction and shows an antidiabetic effect in mice. However, it contains a nitrosamine moiety that is often mutagenic and carcinogenic. Therefore, we previously designed and synthesized methoxime-3,4-dephostatin as a nitrosamine-free analogue

Induction of cellular differentiation and apoptosis by signal transduction inhibitors.

K Umezawa

Advances in enzyme regulation, 37, 393-401 (1997-01-01)

We have isolated signal transduction inhibitors of low molecular weight from microorganisms and plants. Since inducers of differentiation and apoptosis may be developed as new anticancer agents, we have studied induction of differentiation and apoptosis in neoplastic cells by our

Protein tyrosine phosphatase 1B inhibition: opportunities and challenges.

Gang Liu

Current medicinal chemistry, 10(15), 1407-1421 (2003-07-23)

Protein tyrosine phosphatase 1B (PTP1B) has been implicated as one of the key negative regulators of insulin and leptin signal transduction pathways. PTP1B deficient mice are more sensitive to insulin, and have improved glycemic control and resistance to diet-induced obesity

Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells.

S Wakino et al.

The Journal of biological chemistry, 276(50), 47650-47657 (2001-10-13)

The cyclin-dependent kinase inhibitor p21(Cip1) is up-regulated in response to mitogenic stimulation in various cells. PPARgamma ligands troglitazone (TRO, 10 microm) and rosiglitazone (RSG, 10 microm) attenuated the induction of p21(Cip1) protein by platelet-derived growth factor (PDGF) and insulin without

Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor.

Laurent Gaté et al.

Biochemical pharmacology, 65(10), 1611-1622 (2003-05-20)

Glutathione S-transferase pi (GSTpi; EC 2.5.1.18) has been shown recently to be a regulator of mitogen-activated protein kinases (MAPK). We have developed, by chronic exposure of HL60 cells to increasing concentrations of a peptidomimetic GSTpi inhibitor TLK199, a 10-fold resistant

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