D6152

Domoic acid

≥90% (HPLC)

• 실험식(Hill 표기법): C₁₅H₂₁NO₆
• CAS Number: 14277-97-5
• Molecular Weight: 311.33
• Beilstein: 46376
• MDL number: MFCD06795841
• UNSPSC 코드: 12352202
• PubChem Substance ID: 24894006
• NACRES: NA.77

속성

• 분석: ≥90% (HPLC)
• 형태: powder
• 저장 온도: −20°C
• SMILES string: OC([C@H](C)/C=C/C=C([C@@H]1[C@H](CC(O)=O)[C@@H](C(O)=O)NC1)/C)=O
• InChI: 1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4-/t9-,10+,11-,13+/m1/s1
• InChI key: VZFRNCSOCOPNDB-AOKDLOFSSA-N
• 유전자 정보: human ... GRIK1(2897)

설명

일반 설명

Domoic acid, a heterocyclic amino acid neurotoxin is synthesized by various marine algaes. It possess some structural similarity to kainic acid.

애플리케이션

Domoic acid has been used:

• as an excitatory neurotoxin to determine brain transcriptional response
• to study its cytotoxic, genotoxic and immunotoxic effects on the marine mussel M. edulis
• to study its neurobehavioral effects on mouse fetuses

생화학적/생리학적 작용

Domoic acid is a potent agonist at receptors for excitatory amino acids glutamate and kainate. It has highest affinity for AMPA/kainate receptor of any kainate agonist. It can causes excessive excitation of neurons leading to depletion of energy stores.

Domoic acid serves as an antihelminthic. It is capable of binding and stimulating the kainic acid glutamate receptor in the central nervous system.

Potent glutamate receptor and kainate receptor agonist.

특징 및 장점

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This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H370
• 예방조치 성명서: P260 - P264 - P270 - P301 + P312 - P308 + P311 - P405
• Hazard Classifications: Acute Tox. 4 Oral - STOT SE 1
• 표적 기관: Central nervous system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves