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Merck
모든 사진(1)

주요 문서

C6770

Sigma-Aldrich

Carbadox

동의어(들):

3-(2-Quinoxalinylmethylene)carbazic acid methyl ester N,N′-dioxide

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About This Item

실험식(Hill 표기법):
C11H10N4O4
CAS Number:
Molecular Weight:
262.22
EC Number:
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.85

양식

powder

solubility

1 M NaOH: 50 mg/mL

항생제 활성 스펙트럼

Gram-negative bacteria
Gram-positive bacteria

동작 모드

DNA synthesis | interferes

저장 온도

2-8°C

SMILES string

COC(=O)N\N=C\c1cn(=O)c2ccccc2n1=O

InChI

1S/C11H10N4O4/c1-19-11(16)13-12-6-8-7-14(17)9-4-2-3-5-10(9)15(8)18/h2-7H,1H3,(H,13,16)/b12-6+

InChI key

OVGGLBAWFMIPPY-WUXMJOGZSA-N

애플리케이션

Carbadox has been used to suppress aldosterone production, to study the spread of shiga toxin-producing Escherichia coli (STEC) strains,[1] and to compare different antimicrobial activities.[2]

생화학적/생리학적 작용

Carbadox is a quinoxaline-di-N-oxide antibiotic that is generally used in feed to swine to prevent dysentery and improve feed efficiency.[3] It inhibits bacteria by intercalation and induction of mutations in bacterial genome.[4]

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

픽토그램

FlameHealth hazardExclamation mark

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Flam. Sol. 1

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 3

Flash Point (°F)

64.4 °F - closed cup

Flash Point (°C)

18 °C - closed cup


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시험 성적서(COA)

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문서 라이브러리 방문

Torey Looft et al.
Frontiers in microbiology, 5, 276-276 (2014-06-25)
Antibiotics are used in livestock and poultry production to treat and prevent disease as well as to promote animal growth. Carbadox is an in-feed antibiotic that is widely used in swine production to prevent dysentery and to improve feed efficiency.
T Hayashi et al.
Antimicrobial agents and chemotherapy, 32(4), 458-461 (1988-04-01)
Sedecamycin (lankacidin A), one of the lankacidin-group antibiotics, showed potent activity against Treponema hyodysenteriae. The MICs of sedecamycin against 79 field isolates of T. hyodysenteriae ranged from 0.78 to 12.5 micrograms/ml, the MIC for 90% of the strains tested (MIC90)
Thaddeus B Stanton et al.
Applied and environmental microbiology, 74(10), 2950-2956 (2008-03-25)
Brachyspira hyodysenteriae is an anaerobic spirochete and the etiologic agent of swine dysentery. The genome of this spirochete contains a mitomycin C-inducible, prophage-like gene transfer agent designated VSH-1. VSH-1 particles package random 7.5-kb fragments of the B. hyodysenteriae genome and
M C Walsh et al.
Journal of animal science, 90(8), 2599-2608 (2012-02-22)
The objective of this study was to evaluate the effects of water-delivered, direct-fed microbials (DFM) or organic acids on intestinal morphology and active nutrient absorption in weanling pigs after deliberate Salmonella infection. Pigs (n = 88) were weaned at 19
Amisha D Shah et al.
Environmental science & technology, 40(23), 7228-7235 (2006-12-22)
The potential release of carbadox (CDX), a commonly used antibacterial agent in swine husbandry, into water systems is of a concern due to its carcinogenic and genotoxic effects. Until this study, the reactivity of carbadox (possessing quinoxaline N,N'-dioxide and hydrazone

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