C5863

Anti-Calcium Channel (β₄ Subunit) (Voltage Gated Ca²⁺ Channel) antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

• MDL number: MFCD04974685
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: fractionated antiserum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 종 반응성: human, rat, mouse
• 농도: ~1 mg/mL
• 기술: western blot: 5-10 μg/mL using brain tissue lysate
• UniProt 수납 번호: O00305
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CACNB4(785) ; mouse ... Cacnb4(12298) ; rat ... Cacnb4(58942)

설명

일반 설명

The gene CACNB4 (Calcium channel voltage-dependent subunit beta 4) is mapped to human chromosome 2q22-23. It is present at the membrane as well as the nucleus.

특이성

Specifically recognizes a splice variant of β₄ (55 kDa).

면역원

synthetic peptide derived from the rat β₄ calcium channel subunit conjugated to KLH.

애플리케이션

Anti-Calcium Channel (β-4 subunit) antibody produced in rabbit is suitable for western blot at a concentration of 5-10μg/mL using brain tissue lysate.
The antibody has been used for:

• western blotting of proteins extracted from different brain regions of the mouse
• western blotting of proteins isolated from primary culture of mouse cerebral cortical neurons

생화학적/생리학적 작용

The CACNB4 (Calcium channel voltage-dependent subunit β 4) is an intracellular regulatory subunit of voltage-activated calcium channels that has significant impact on membrane expression and electrophysical characteristics of the channel. Calcium channel β subunits regulate voltage-dependent calcium currents through direct interaction with α1 subunits. Mutations in CACNB4 are associated with idiopathic generalized epilepsy and episodic ataxia. CACNB4 interacts with heterochromatin protein 1γ (HP1γ). The interaction attenuates the gene silencing activity by HP1.

물리적 형태

Solution in phosphate buffered saline containing 0.08% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids