C5366

Chlorisondamine diiodide

≥98% (HPLC), nicotinic acetylcholine receptor antagonist, solid

• 동의어(들): 4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide
• 실험식(Hill 표기법): C₁₄H₂₀Cl₄I₂N₂
• CAS 번호: 96750-66-2
• Molecular Weight: 611.94
• UNSPSC Code: 12352116
• PubChem Substance ID: 24724443
• NACRES: NA.77
• MDL number: MFCD01074794
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

속성

• 제품 이름: Chlorisondamine diiodide, ≥98% (HPLC), white, solid
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: white
• solubility: H₂O: ≥2 mg/mL, DMSO: >20 mg/mL
• storage temp.: 2-8°C
• SMILES string: [I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
• InChI: 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
• InChI key: FPNVAOZHQUJJJQ-UHFFFAOYSA-L

설명

Application

Chlorisondamine diiodide has been used:

• as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
• as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
• as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress

Biochem/physiol Actions

Chlorisondamine diiodide mediates ganglionic and central blockade.

Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302,H400
• pcodes: P273 - P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• 저장 등급: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves