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Merck
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Key Documents

C3241

Sigma-Aldrich

Anti-CCR-7 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

동의어(들):

Anti-C-C Chemokine Receptor 7

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About This Item

MDL number:
UNSPSC 코드:
51111800
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

종 반응성

human

재고 정보

not available in Japan

농도

~1 mg/mL

기술

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

유전자 정보

human ... CCR7(1236)
mouse ... Ccr7(12775)
rat ... Ccr7(287673)

면역원

synthetic peptide corresponding to the C-terminal domain of human C-C chemokine receptor 7 (CCR7), conjugated to KLH.

생화학적/생리학적 작용

CCR-7 is a G protein-coupled receptor that activates B and T lymphocytes. It mediates the effects of Epstein-Barr virus on B lymphocytes, regulates the migration of memory T cells to sites of inflammation and stimulates dendritic cell maturation.

물리적 형태

Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Praveen Akuthota et al.
American journal of respiratory cell and molecular biology, 48(6), 758-764 (2013-03-02)
Human eosinophils display directed chemotactic activity toward an array of soluble chemokines. Eosinophils have been observed to migrate to draining lymph nodes in experimental models of allergic inflammation, yet it is unknown whether eosinophils express CCR7, a key chemokine receptor
Karin Schaeuble et al.
Journal of cell science, 125(Pt 19), 4463-4474 (2012-07-17)
The chemokine receptor CCR7 is essential for lymphocyte and dendritic cell homing to secondary lymphoid organs. Owing to the ability to induce directional migration, CCR7 and its ligands CCL19 and CCL21 are pivotal for the regulation of the immune system.
Marc-André Allaire et al.
Immunology letters, 146(1-2), 70-73 (2012-06-05)
Prostaglandin E(2) (PGE(2)) induces the expression of C-C chemokine receptor type 7 (CCR7) on human monocytes, thereby enabling their subsequent migration in response to CCL19 and CCL21, the natural ligands for CCR7. To date, important mediators of PGE(2)-mediated monocyte migration

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