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Merck
모든 사진(2)

문서

C3021

Sigma-Aldrich

Dicyanocobinamide

≥93%

동의어(들):

Cobinamide dicyanide, Etiocobalamin, Factor B

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C50H72CoN13O8
CAS Number:
27792-36-5
Molecular Weight:
1042.12
MDL number:
MFCD00056330
UNSPSC 코드:
12352205
PubChem Substance ID:
24892558
NACRES:
NA.79

생물학적 소스

synthetic (organic)

Quality Level

200

분석

≥93%

형태

powder

불순물

≤0.1% vitamin B12

색상

purple to very dark purple

저장 온도

−20°C

SMILES string

N#C[Co]C#N.C[C@H](O)CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)C2N=C1C(C)=C3N=C(C=C4N=C(C(C)=C5N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O

InChI

1S/C48H73N11O8.2CN.Co/c1-23(60)22-55-38(67)16-17-45(6)29(18-35(52)64)43-48(9)47(8,21-37(54)66)28(12-15-34(51)63)40(59-48)25(3)42-46(7,20-36(53)65)26(10-13-32(49)61)30(56-42)19-31-44(4,5)27(11-14-33(50)62)39(57-31)24(2)41(45)58-43;2*1-2;/h19,23,26-29,43,59-60H,10-18,20-22H2,1-9H3,(H2,49,61)(H2,50,62)(H2,51,63)(H2,52,64)(H2,53,65)(H2,54,66)(H,55,67);;;/b30-19-,39-24-,40-25-;;;/t23-,26+,27+,28+,29-,43?,45+,46-,47-,48-;;;/m0.../s1

InChI key

NJATWHPHZUGTHR-GXEWULDJSA-N

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관련 카테고리

일반 설명

Dicyanocobinamide, also known as factor b is a coenzyme B12 precursor. It has a corrin ring structure with four of the six coordination sites of the cobalt (Co) atom being the pyrrole nitrogen atoms.

애플리케이션

Dicyanocobinamide has been used for the crystallization of vitamin B12-binding protein (BtuF). It has also been used for the destabilization of BtuCD-BtuF Interaction.
For use in determining non-intrinsic factor (R protein) in intrinsic factor preparations.

생화학적/생리학적 작용

Dicyanocobinamide (Cbi) functions as a soluble guanylate cyclase (sGC) co-activator and targets the N-terminal regulatory regions. This action is similar to the effect of forskolin on adenylyl cyclases. Dicyanocobinamide elevates the intracellular cyclic guanosine monophosphate (cGMP) levels and exhibits vasorelaxant activity in rats. It is used along with various cobalamins in studies of the inhibition of HIV-1 integrase and nitric oxide synthase.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

The Different Effects of Substrates and Nucleotides on the Complex Formation of ABC Transporters
Fiorentino F, et al.
Structure, 27(4), 651-659 (2019)
Conformational change of a tryptophan residue in BtuF facilitates binding and transport of cobinamide by the vitamin B12 transporter BtuCD-F
Mireku SA, et al.
Scientific reports, 7, 41575-41575 (2017)
Inhibition of nitric oxide synthase by cobalamins and cobinamides
Weinberg JB, et al.
Free Radical Biology & Medicine, 46(12), 1626-1632 (2009)
Longxing Cao et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(47), 13438-13443 (2016-11-09)
Clearance of dead cells is critical for maintaining homeostasis and prevents autoimmunity and inflammation. When cells undergo apoptosis and necrosis, specific markers are exposed and recognized by the receptors on phagocytes. DEC205 (CD205) is an endocytotic receptor on dendritic cells
Koustav Ganguly et al.
Particle and fibre toxicology, 14(1), 19-19 (2017-06-24)
The death toll associated with inhaled ambient particulate matter (PM) is attributed mainly to cardio-vascular rather than pulmonary effects. However, it is unclear whether the key event for cardiovascular impairment is particle translocation from lung to circulation (direct effect) or
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