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Merck
모든 사진(2)

문서

C2993

Sigma-Aldrich

Anti-CRMP2 antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

동의어(들):

Anti-Collapsin Response Mediator Protein 2, Anti-Dihydropyriminidase Related Protein-2 (DRP2, DRP-2, DHPRP2), Anti-Dihydropyriminidase-like 2 (DPYSL2), Anti-TOAD-64

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모든 사진(2)

About This Item

MDL number:
MFCD03456049
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

형태

buffered aqueous solution

분자량

antigen ~62 kDa

종 반응성

human, mouse, rat

향상된 검증

recombinant expression
Learn more about Antibody Enhanced Validation

농도

~1.0 mg/mL

기술

western blot: 0.1-0.2 μg/mL using HeLa whole cell lysate and mouse brain extract (S1 fraction)

UniProt 수납 번호

Q16555

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... DPYSL2(1808)
mouse ... Dpysl2(12934)
rat ... Dpysl2(25416)

일반 설명

Collapsin response mediator proteins CRMPs) consist of a family of cytosolic phosphoproteins expressed in the nervous system and involved in neuronal differentiation and axonal guidance.

애플리케이션

Anti-CRMP2 antibody produced in rabbit has been used in:
  • western blotting
  • immunohistofluorescence
  • epifluorescence imaging
  • coimmunoprecipitation

생화학적/생리학적 작용

CRMPs are a part of the collapsin/semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. CRMP2 is upregulated during development, and appears to be crucial for axon outgrowth. Glycogen synthase kinase 3 beta (GSK-3b) phosphorylates and inactivates CRMP-2 downstream of the phosphoinositide-3-kinase (PI3K/Akt) pathway, thus regulating neuronal polarity. CRMP2 interacts with tubulin dimers, kinesin-1 and WASP-family verprolin homologous protein 1 (WAVE1) complex to regulate axon outgrowth.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Jennifer Y Xie et al.
Pain, 157(9), 2124-2140 (2016-08-19)
Uncoupling the protein-protein interaction between collapsin response mediator protein 2 (CRMP2) and N-type voltage-gated calcium channel (CaV2.2) with an allosteric CRMP2-derived peptide (CBD3) is antinociceptive in rodent models of inflammatory and neuropathic pain. We investigated the efficacy, duration of action
Erik Thomas Dustrude et al.
Channels (Austin, Tex.), 11(4), 316-328 (2017-03-10)
The neuronal collapsin response mediator protein 2 (CRMP2) undergoes several posttranslational modifications that codify its functions. Most recently, CRMP2 SUMOylation (addition of small ubiquitin like modifier (SUMO)) was identified as a key regulatory step within a modification program that codes
Efficacy of (S)-Lacosamide in preclinical models of cephalic pain
Moutal A, et al.
Pain reports, 1(1) (2016)
CRMP2 phosphorylation drives glioblastoma cell proliferation
Moutal A, et al.
Molecular Neurobiology, 55(5), 4403-4416 (2018)
Aubin Moutal et al.
Pain, 157(7), 1448-1463 (2016-03-12)
Chronic pain affects the life of millions of people. Current treatments have deleterious side effects. We have advanced a strategy for targeting protein interactions which regulate the N-type voltage-gated calcium (CaV2.2) channel as an alternative to direct channel block. Peptides
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