C2247

CPPHA

≥98% (HPLC)

• 동의어(들): N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide, N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
• 실험식(Hill 표기법): C₂₂H₁₅ClN₂O₄
• CAS Number: 693288-97-0
• Molecular Weight: 406.82
• MDL number: MFCD12912405
• UNSPSC 코드: 12352209
• PubChem Substance ID: 329774983
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: solid
• 저장 조건: desiccated
• solubility: DMSO: >20 mg/mL
• 주관자: Merck & Co., Inc., Kenilworth, NJ, U.S.
• 저장 온도: −20°C
• SMILES string: Oc1ccccc1C(=O)Nc2ccc(Cl)cc2CN3C(=O)c4ccccc4C3=O
• InChI: 1S/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27)
• InChI key: UFOUABRZSDGGAZ-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.

특징 및 장점

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This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H410
• 예방조치 성명서: P273 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable