C1368
Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide
≥98% (HPLC), solid
동의어(들):
Aurora Kinase Inhibitor III
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C21H18F3N5O
CAS Number:
Molecular Weight:
413.40
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
Quality Level
분석
≥98% (HPLC)
형태
solid
색상
white
solubility
H2O: <2 mg/mL
DMSO: >7 mg/mL
저장 온도
2-8°C
SMILES string
FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1
InChI
1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29)
InChI key
RDTDWGQDFJPTPD-UHFFFAOYSA-N
생화학적/생리학적 작용
ATP-competitive Aurora A kinase inhibitor with IC50 = 42 nM
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Pooja Mohan et al.
Oncotarget, 4(1), 80-93 (2013-01-19)
Malignant peripheral nerve sheath tumours (MPNST) are rare, hereditary cancers associated with neurofibromatosis type I. MPNSTs lack effective treatment options as they often resist chemotherapies and have high rates of disease recurrence. Aurora kinase A (AURKA) is an emerging target
Igor Astsaturov et al.
Science signaling, 3(140), ra67-ra67 (2010-09-23)
Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes closely linked to therapeutic targets would be enriched for determinants of drug resistance. We developed
Mahendra K Singh et al.
Cancer research, 70(21), 8907-8916 (2010-10-14)
Elevated expression of the NEDD9/HEF1/Cas-L scaffolding protein promotes tumor cell invasion and metastasis in multiple cancer cell types. Conversely, generation of mammary tumors in the mouse mammary tumor virus (MMTV)-polyoma virus middle T (PyVT) genetic model is delayed by a
Ming Shen Tham et al.
Nature communications, 15(1), 371-371 (2024-01-09)
Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA's role in regulating renal cyst development we conditionally deleted the gene in mouse models of Autosomal Dominant PKD (ADPKD)
Qiong Zhang et al.
Journal of the American Chemical Society, 128(7), 2182-2183 (2006-02-16)
The epidermal growth factor receptor (EGFR) tyrosine kinase was one of the first receptor tyrosine kinases to be targeted for drug development by the pharmaceutical industry due to its ubiquitous overexpression in a variety of tumors. Despite the validation of
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