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Merck
모든 사진(1)

문서

C124

Sigma-Aldrich

β-CFT naphthalenedisulfonate monohydrate

solid

동의어(들):

(−)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate monohydrate, WIN 35,428 naphthalenedisulfonate monohydrate

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C16H20FNO2 · C10H8O6S2 · H2O
CAS Number:
77210-32-3
Molecular Weight:
583.65
MDL number:
MFCD11044874
UNSPSC 코드:
12352200
PubChem Substance ID:
24892389
NACRES:
NA.77

형태

solid

광학 활성

[α]25/D −62.5°, c = 1.0 in H2O(lit.)

약물 제어

USDEA Schedule II

색상

white

solubility

H2O: soluble

저장 온도

2-8°C

SMILES string

O.OS(=O)(=O)c1cccc2c(cccc12)S(O)(=O)=O.COC(=O)[C@@H]3C4CCC(C[C@@H]3c5ccc(F)cc5)N4C

InChI

1S/C16H20FNO2.C10H8O6S2.H2O/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10;11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16;/h3-6,12-15H,7-9H2,1-2H3;1-6H,(H,11,12,13)(H,14,15,16);1H2/t12-,13+,14+,15-;;/m0../s1

InChI key

XSJPWVYASBDEJI-YEVYTSHMSA-N

생화학적/생리학적 작용

Cocaine analog that inhibits the dopamine, norepinephrine, and serotonin transporters with Kis of 26.1 nM, 31.9 nM, and 127 nM, respectively. [11C]-β-CFT and [18F]-β-CFT are ligands for PET imaging of the dopamine transporter in vivo.

특징 및 장점

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

픽토그램

Skull and crossbonesHealth hazard
GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H300 + H310 + H330,H317,H361

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - Skin Sens. 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

M Haaparanta et al.
Synapse (New York, N.Y.), 23(4), 321-327 (1996-08-01)
We describe the 18F-radiolabelling synthesis (18F; T(1/2) = 109.8 min) of 2-beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane (also known as CFT or WIN 35,428) and the biodistribution of this compound in rats. 18F-labelled CFT has high chemical and radiochemical purity and relatively high specific
U Scheffel et al.
Synapse (New York, N.Y.), 23(2), 61-69 (1996-06-01)
[11C]WIN 35,428 (also designated [11C]CFT) is now being used in several positron emission tomography (PET) centers to image dopamine (DA) transporter sites in the mammalian brain. Whether and to what extent in vivo WIN 35,428 binding is influenced by intra-
Thomas E Wooters et al.
Behavioural brain research, 219(1), 98-107 (2011-01-12)
Rats raised in an enriched condition (EC) are less sensitive to the locomotor effects of stimulant drugs than rats raised in an impoverished condition (IC). Methylphenidate (MPD), a primary pharmacotherapy for attention-deficit/hyperactivity disorder, has abuse potential. This study determined whether
Y Ouchi et al.
Annals of neurology, 45(5), 601-610 (1999-05-13)
We investigated changes in the kinetics in the binding of the dopamine transporter probe 2-beta-carbomethoxy-3beta-(4-[11C]fluorophenyl)tropane (beta-CFT) in living brain by compartmental analysis, using positron emission tomography in unmedicated patients with Parkinson's disease (PD) (Hoehn and Yahr stages I-II). With dynamic
Yan-Fen Zhang et al.
Nuclear medicine and biology, 38(8), 1205-1212 (2011-07-12)
Alterations of dopamine in striatal presynaptic terminals play an important role in the hypoxic-ischemic (HI) brain injury. Quantification of DAT levels in the presynaptic site using (11)C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane ((11)C-CFT) with positron emission tomography (PET) was applied in studies for Parkinson's disease.
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