BM0015

BMS-309403

≥98% (HPLC)

• 동의어(들): 2-[[2′-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1′-biphenyl]-3-yl]oxy]acetic acid, BMS 309403
• 실험식(Hill 표기법): C₃₁H₂₆N₂O₃
• CAS Number: 300657-03-8
• Molecular Weight: 474.55
• MDL number: MFCD09991687
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329774359
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 10 mg/mL, clear
• 저장 온도: room temp
• SMILES string: O=C(O)COC1=CC(C2=CC=CC=C2N3C(CC)=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=N3)=CC=C1

설명

생화학적/생리학적 작용

BMS-309403 is a potent and selective inhibitor of fatty acid binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP, aP2). FABP4 is an intracellular lipid-binding protein responsible for the transportation of fatty acids. It is expressed primarily in adipose tissue and is associated with inflammation, obesity, diabetes and cardiovascular diseases. BMS309403 interacts with the fatty-acid-binding pocket within the interior of FABP4 and has been shown to competitively inhibit fatty acid binding with a Ki value < 2 nM. BMS309403 is orally active and has been shown to reduce atherosclerosis in mice studies.

BMS-309403 is a potent and selective inhibitor of fatty acid binding protein 4 (FABP4).

특징 및 장점

BMS-309403 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

법적 정보

Sold for research purposes only under agreement from BMS.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable