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Merck
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주요 문서

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B109

Sigma-Aldrich

nor-Binaltorphimine dihydrochloride

solid

동의어(들):

nor-BNI dihydrochloride

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C40H43N3O6 · 2HCl
CAS Number:
113158-34-2
Molecular Weight:
734.71
MDL number:
MFCD00069374
UNSPSC 코드:
12352103
PubChem Substance ID:
329773161

형태

solid

색상

tan

solubility

artificial CSF: 2 mg/mL (prepare with sonication for 4 minutes)
H2O: 6.0 mg/mL (aqueous solutions are highly unstable and should be freshly prepared.)
ethanol: soluble

SMILES string

Cl[H].Cl[H].Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6[nH]c7[C@@H]8Oc9c(O)ccc%10C[C@H]%11N(CC[C@@]8(c9%10)[C@@]%11(O)Cc7c6C[C@@]35O)CC%12CC%12)CC%13CC%13

InChI

1S/C40H43N3O6.2ClH/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19;;/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2;2*1H/t27-,28-,35+,36+,37+,38+,39-,40-;;/m1../s1

InChI key

JOJPJLHRMGPDPV-LZQROVCBSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Highly selective κ-opioid receptor antagonist.

교체됨

제품 번호
설명
가격

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

M Dimitrijević et al.
Immunopharmacology, 49(3), 255-262 (2000-09-21)
We have previously demonstrated that central application of leucine-enkephalin (Leu-Enk) elicits potentiation and suppression of humoral immune responses through OP(1) (delta) and OP(2) (kappa) receptors, respectively. Interestingly, both effects were found to be additionally dependent on OP(3) (mu) receptor function.
S A Hjorth et al.
Molecular pharmacology, 47(6), 1089-1094 (1995-06-01)
The structural determinants for the selective binding of the nonpeptide opioid receptor antagonist nor-binaltorphimine (nor-BNI) to the kappa-opioid receptor were characterized using a systematic series of chimeras between the kappa receptor and the homologous mu-opioid receptor. All 10 chimeric constructs
M C Ko et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1113-1120 (1999-11-24)
Systemic administration of nor-binaltorphimine (nor-BNI) produces a long-lasting kappa-opioid receptor (kappaOR) antagonism and has kappa(1)-selectivity in nonhuman primates. The aim of this study was to establish the pharmacological basis of central kappaOR antagonism in rhesus monkeys (Macaca mulatta). After intracisternal
A E Takemori et al.
The Journal of pharmacology and experimental therapeutics, 246(1), 255-258 (1988-07-01)
Previously, we reported on an opioid antagonist, nor-binaltorphimine (nor-BNI), that had high selectivity for kappa opioid receptors in smooth muscle preparations. In this study, nor-BNI administered either s.c. or i.c.v. was shown to antagonize significantly the antinociceptive effects of the
Juliana Almeida da Silva et al.
European journal of pharmacology, 698(1-3), 235-245 (2013-02-12)
The chemical neuroanatomy and the effects of central administration of opioid antagonists on the innate fear-induced responses elicited by electrical (at escape behaviour threshold) stimulation of the midbrain tectum were determined. The aim of the present work was to investigate
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