AV43340

Anti-RNF146 antibody produced in rabbit

IgG fraction of antiserum

• 동의어(들): Anti-DKFZP434O1427, Anti-RP3-351K20.1, Anti-Ring finger protein 146, Anti-dJ351K20.1
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: IgG fraction of antiserum
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: 39 kDa
• 종 반응성: mouse, horse, rat, human
• 농도: 0.5 mg - 1 mg/mL
• 기술: western blot: suitable
• NCBI 수납 번호: NP_112225
• UniProt 수납 번호: Q9NTX7-2
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... RNF146(81847)

설명

일반 설명

Ring finger protein 146 (RNF146, Iduna) is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase which ubiquitinates proteins for degradation by proteosomes. RNF146 is neuroprotective due to its inhibition of Parthanatos via binding with Poly(ADP-ribose) (PAR). RNF146 regulates Wnt signaling via ubiquitylation of auto-PARsylated tankyrase.

특이성

Anti-RNF146 polyclonal antibody reacts with human and mouse ring finger protein 146 proteins.

면역원

Synthetic peptide directed towards the C terminal region of human RNF146

애플리케이션

Anti-RNF146 polyclonal antibody is used to tag ring finger protein 146 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles ring finger protein 146 in Wnt signaling and neuroprotection.

서열

Synthetic peptide located within the following region: AVVAQHSLTQQRLLVSNANQTVPDRSDRSGTDRSVAGGGTVSVSVRSRRP

물리적 형태

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable