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Merck
모든 사진(3)

주요 문서

AV40528

Sigma-Aldrich

Anti-SFRS10 (AB1) antibody produced in rabbit

IgG fraction of antiserum

동의어(들):

Anti-Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)

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About This Item

UNSPSC 코드:
12352203

생물학적 소스

rabbit

결합

unconjugated

항체 형태

IgG fraction of antiserum

항체 생산 유형

primary antibodies

클론

polyclonal

양식

lyophilized powder

분자량

32 kDa

종 반응성

canine, rat, human, rabbit, horse, mouse, pig, bovine

농도

0.5 mg - 1 mg/mL

기술

immunohistochemistry: suitable
western blot: suitable

NCBI 수납 번호

저장 온도

−20°C

유전자 정보

human ... SFRS10(6434)

일반 설명

Transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (TRA2B, SFRS10) is an alternative splicing regulator that itself exists as alternative splice variants. Alternative mRNA splicing provides transcript diversity. SFRS10 binds SMN1/SMN2 RNA and restores full-length (FL)-SMN2 mRNA levels in vitro. Deficiency of SFRS10 results in early embryonic lethality.

특이성

Anti-SFRS10 (AB1) polyclonal antibody reacts with canine, chicken, human, mouse, rat, pig, and bovine transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) proteins.

면역원

The immunogen for anti-SFRS10 antibody: synthetic peptide derected towards the N terminal of human SFRS10

애플리케이션

Anti-SFRS10 (AB1) polyclonal antibody is used to tag transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) in the regulation of alternative pre-mRNA splicing.

서열

Synthetic peptide located within the following region: MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKS

물리적 형태

Lyophilized from PBS buffer with 2% sucrose

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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문서 라이브러리 방문

Yupu Diao et al.
Cerebral cortex (New York, N.Y. : 1991), 28(4), 1168-1182 (2017-03-24)
The dorsal Lateral Geniculate Nucleus (dLGN) is the primary image-forming target of the retina and shares a reciprocal connection with primary visual cortex (V1). Previous studies showed that corticothalamic input is essential for the development of thalamocortical projections, but less
Somsakul Pop Wongpalee et al.
eLife, 5 (2016-11-25)
Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found that PTBP1 binding
Devi Krishna Priya Karunakaran et al.
Gene expression patterns : GEP, 13(8), 425-436 (2013-08-13)
Processing of mRNAs including, alternative splicing (AS), mRNA transport and translation regulation are crucial to eukaryotic gene expression. For example, >90% of the genes in the human genome are known to undergo alternative splicing thereby expanding the proteome production capacity
Thomas C Whisenant et al.
PloS one, 10(12), e0144409-e0144409 (2015-12-08)
Activation of CD4 T cells is a reaction to challenges such as microbial pathogens, cancer and toxins that defines adaptive immune responses. The roles of T cell receptor crosslinking, intracellular signaling, and transcription factor activation are well described, but the

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