재조합
expressed in E. coli
분석
>80% (SDS-PAGE)
양식
buffered aqueous solution
분자량
predicted mol wt 33 kDa
정제법
immobilized metal affinity chromatography (IMAC)
농도
≥0.5 mg/mL
면역원 서열
KCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEK
Ensembl | 인체 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... XRCC4(7518)
일반 설명
Recombinant protein fragment of Human XRCC4 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. X-ray repair cross-complementing protein 4 (XRCC4) is also known as DNA repair protein XRCC4. It is mapped to human chromosome locus 5q14.2. It mediates joining of DNA double strand breaks during DNA repair.
애플리케이션
Suitable as a blocking agent using corresponding antibodies.
생화학적/생리학적 작용
X-ray repair cross-complementing protein 4 (XRCC4) interacts with XRCC4-like factor (XLF) and DNA ligase IV in mediating nonhomologous end joining (NHEJ) cascade in DNA repair. A mutation in the XRCC4 is associated with adult-onset progressive encephalocardiomyopathy and ataxia. Patients with polymorphisms in XRCC4 gene are susceptible to schizophrenia. Single nucleotide polymorphisms in XRCC4 associates with high risk for cancer development. Mutations in XRCC4 leads to growth failure resulting in short stature accompanied by facial dysmorphism.(10)
결합
Corresponding Antibody HPA006801.
물리적 형태
Solution in 1 M urea-PBS, pH 7.4
제조 메모
The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
법적 정보
Prestige Antigens is a trademark of Sigma-Aldrich Co. LLC
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability
Rosin N, et al.
Human Molecular Genetics, 24(13), 3708-3717 (2015)
An updated meta-analysis of XRCC4 polymorphisms and cancer risk based on 31 case-control studies
Shao N, et al.
Cancer Biomarkers : Section A of Disease Markers, 12(1), 37-47 (2013)
Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA
Brouwer I, et al.
Nature, 535(7613), 566-566 (2016)
XRCC4 rs6869366 polymorphism is associated with susceptibility to both nicotine dependence and/or schizophrenia
Pehlivan S, et al.
Archives of Clinical Psychiatry, 45(3), 53-56 (2018)
A nonsense mutation of human XRCC4 is associated with adult-onset progressive encephalocardiomyopathy
Bee L, et al.
EMBO Molecular Medicine, 7(7), 918-929 (2015)
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