A7986

Atovaquone

≥98% (HPLC), powder, anti-protozoal agent

• 동의어(들): Mepron, trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
• 실험식(Hill 표기법): C₂₂H₁₉ClO₃
• CAS Number: 95233-18-4
• Molecular Weight: 366.84
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329770944
• NACRES: NA.77

속성

• product name: Atovaquone, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: yellow
• solubility: DMSO: >10 mg/mL
• 주관자: GlaxoSmithKline
• 저장 온도: −20°C
• SMILES string: OC1=C([C@H]2CC[C@@H](CC2)c3ccc(Cl)cc3)C(=O)c4ccccc4C1=O
• InChI: 1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,26H,5-8H2/t13-,15-
• InChI key: KUCQYCKVKVOKAY-CTYIDZIISA-N

설명

애플리케이션

Atovaquone inhibits the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. In addition to its use as a treatment for toxoplasmosis, atovaquone has antimalarial properties and prevents pneumocystis pneumonia post-renal transplant.

생화학적/생리학적 작용

Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It is an analog of protozoan mitochondrial protein ubiquinone, and acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket.

특징 및 장점

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable