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Merck
모든 사진(2)

주요 문서

A5475

Sigma-Aldrich

ALX-1393

>98% (HPLC), powder

동의어(들):

O-[(2-Benzyloxyphenyl-3-flurophenyl)methyl]-L-serine

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About This Item

실험식(Hill 표기법):
C23H22NO4F
Molecular Weight:
395.42
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:

분석

>98% (HPLC)

양식

powder

색상

white

solubility

DMSO: soluble ~20 mg/mL

배송 상태

wet ice

저장 온도

−20°C

SMILES string

N[C@@H](COC(c1cccc(F)c1)c2ccccc2OCc3ccccc3)C(O)=O

InChI

1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1

InChI key

ADUSZEGHFWRTQS-AIBWNMTMSA-N

애플리케이션

ALX-1393 is a GlyT-2 glycine transporter inhibitor and GlyT2 may be a novel therapeutic target for the treatment of overactive bladder and/or bladder hypersensitive disorders such as bladder pain syndrome/interstitial cystitis.

생화학적/생리학적 작용

GlyT-2 glycine transporter inhibitor.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Glycine Transporter Type 2 (GlyT2) Inhibitor Ameliorates Bladder Overactivity and Nociceptive Behavior in Rats
Yoshikawa, S., et al.
European Urology, doi: 10-doi: 10 (2012)
Birgit Nimmervoll et al.
Neuroreport, 22(10), 509-513 (2011-06-15)
To investigate whether glycine receptors influence radial migration in the neocortex, we analyzed the effect of glycine and the glycinergic antagonist strychnine, on the distribution of 5-bromo-2'deoxyuridine-labeled neurons in organotypic slice cultures from embryonic mice cortices. Application of glycine impeded
Hyo-Jin Jeong et al.
British journal of pharmacology, 161(4), 925-935 (2010-09-24)
The arachidonyl-amino acid N-arachidonyl-glycine (NAGly) is an endogenous lipid, generated within the spinal cord and producing spinally mediated analgesia via non-cannabinoid mechanisms. In this study we examined the actions of NAGly on neurons within the superficial dorsal horn, a key
Thomas M Ackermann et al.
ChemMedChem, 16(1), 199-215 (2020-08-01)
This study describes the first binding assay for glycine transporter 2 (GlyT2) following the concept of MS Binding Assays. The selective GlyT2 inhibitor Org25543 was employed as a reporter ligand and it was quantified with a highly sensitive and rapid

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