분석
>98% (HPLC)
양식
powder
색상
white
solubility
DMSO: soluble ~20 mg/mL
배송 상태
wet ice
저장 온도
−20°C
SMILES string
N[C@@H](COC(c1cccc(F)c1)c2ccccc2OCc3ccccc3)C(O)=O
InChI
1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1
InChI key
ADUSZEGHFWRTQS-AIBWNMTMSA-N
애플리케이션
ALX-1393 is a GlyT-2 glycine transporter inhibitor and GlyT2 may be a novel therapeutic target for the treatment of overactive bladder and/or bladder hypersensitive disorders such as bladder pain syndrome/interstitial cystitis.
생화학적/생리학적 작용
GlyT-2 glycine transporter inhibitor.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
Glycine Transporter Type 2 (GlyT2) Inhibitor Ameliorates Bladder Overactivity and Nociceptive Behavior in Rats
European Urology, doi: 10-doi: 10 (2012)
Neuroreport, 22(10), 509-513 (2011-06-15)
To investigate whether glycine receptors influence radial migration in the neocortex, we analyzed the effect of glycine and the glycinergic antagonist strychnine, on the distribution of 5-bromo-2'deoxyuridine-labeled neurons in organotypic slice cultures from embryonic mice cortices. Application of glycine impeded
British journal of pharmacology, 161(4), 925-935 (2010-09-24)
The arachidonyl-amino acid N-arachidonyl-glycine (NAGly) is an endogenous lipid, generated within the spinal cord and producing spinally mediated analgesia via non-cannabinoid mechanisms. In this study we examined the actions of NAGly on neurons within the superficial dorsal horn, a key
ChemMedChem, 16(1), 199-215 (2020-08-01)
This study describes the first binding assay for glycine transporter 2 (GlyT2) following the concept of MS Binding Assays. The selective GlyT2 inhibitor Org25543 was employed as a reporter ligand and it was quantified with a highly sensitive and rapid
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