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Merck
모든 사진(1)

주요 문서

A4056

Sigma-Aldrich

Amrinone

동의어(들):

5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone

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About This Item

실험식(Hill 표기법):
C10H9N3O
CAS Number:
Molecular Weight:
187.20
EC Number:
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:

분석

≥98% (TLC)

Quality Level

양식

powder

solubility

1 M NaOH: 100 mg/mL

저장 온도

2-8°C

SMILES string

NC1=CC(=CNC1=O)c2ccncc2

InChI

1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

InChI key

RNLQIBCLLYYYFJ-UHFFFAOYSA-N

유전자 정보

human ... PDE3A(5139)
rat ... Pde3a(50678)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action. Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney, liver, and heart.

픽토그램

Skull and crossbones

신호어

Danger

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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시험 성적서(COA)

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문서 라이브러리 방문

M P Rechtman et al.
European journal of pharmacology, 402(3), 255-262 (2000-08-26)
We investigated the effects of amrinone on ischaemia-induced changes in myocardial function in isolated rat hearts. Isolated hearts from male Sprague-Dawley rats (150-275 g) were perfused with physiological salt solution at a constant flow rate. The effects of amrinone (30
Kazuo Komamura et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 11 Suppl 1, S39-S42 (2008-04-17)
Phosphodiesterase (PDE) III inhibitor therapy is effective for treatment of acute decompensated heart failure (ADHF). Nevertheless, this drug is expensive than conventional inotropic agent dobutamine. We compared total medication costs of the patients treated with PDE III inhibitor amrinone therapy
Can Kucuk et al.
The Journal of surgical research, 151(1), 74-79 (2008-05-13)
During some surgical interventions, temporary occlusion of the hepatic blood supply may cause ischemia-reperfusion (IR) injury. Recent studies suggest that type 3 phosphodiesterase inhibitors may have a beneficial effect on liver IR injury. The aim of this study was to
Yoshihiro Ko et al.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 15(5), 311-317 (2009-11-11)
Phosphodiesterase (PDE) III inhibitors have been reported in various cellular protective activities via the cyclic adenosine monophosphate (cAMP) pathway. We investigated the effects of amrinone on ischemia/reperfusion injury and intracellular calcium (Ca2+) handling if utilized as a component of terminal
R Karabulut et al.
Urological research, 30(3), 164-168 (2002-07-12)
Renal ischemia/reperfusion injury could arise as a consequence of clinical conditions such as renal transplantation, shock, cardiac arrest, hemorrhage and renal artery surgery. In this experimental study, we aimed to determine the preventive effects of amrinone on bilateral renal ischemia/reperfusion

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