형태
solid
광학 활성
[α]20/D −5.2°, c = 0.5 in methanol(lit.)
색상
off-white
solubility
H2O: 10 mg/mL
SMILES string
Cl[H].Cl[H].C1C[C@H](COc2cccnc2)N1
애플리케이션
The 5-125I-analog has been used as a selective radioligand for the α4β2 nAChR subtype. Fluorinated analogs have been used for PET imaging of nAChRs.
생화학적/생리학적 작용
Potent and selective neuronal nicotinic acetylcholine receptor (nAChR) agonist.
주의사항
Hygroscopic
법적 정보
Manufactured and sold under exclusive license from Abbott Laboratories.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
J P Sullivan et al.
Neuropharmacology, 35(6), 725-734 (1996-06-01)
The in vitro pharmacological properties of a novel cholinergic channel ligand, A-85380 [3-(2(S)-azetidinylmethoxy)pyridine], were examined using tissue preparations that express different putative nAChR subtypes. In radioligand binding studies, A-85380 is shown to be a potent and selective ligand for the
A G Horti et al.
Nuclear medicine and biology, 25(7), 599-603 (1998-11-06)
The in vivo brain regional distribution of 2-[18F]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followed the regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in
A G Mukhin et al.
Molecular pharmacology, 57(3), 642-649 (2000-02-29)
In an effort to develop selective radioligands for in vivo imaging of neuronal nicotinic acetylcholine receptors (nAChRs), we synthesized 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine (5-iodo-A-85380) and labeled it with (125)I and (123)I. Here we present the results of experiments characterizing this radioiodinated ligand in
M A Abreo et al.
Journal of medicinal chemistry, 39(4), 817-825 (1996-02-16)
Recent evidence indicating the therapeutic potential of cholinergic channel modulators for the treatment of central nervous system (CNS) disorders as well as the diversity of brain neuronal nicotine acetylcholine receptors (nAChRs) have suggested an opportunity to develop subtype-selective nAChR ligands
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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