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Merck
모든 사진(2)

문서

A2324

Sigma-Aldrich

Amikacin sulfate salt

aminoglycoside antibiotic

로그인조직 및 계약 가격 보기


About This Item

CAS Number:
MDL number:
UNSPSC 코드:
51101500
PubChem Substance ID:
NACRES:
NA.85

생물학적 소스

synthetic

형태

powder

농도

691-806 μg/mg (dry)

색상

white to off-white

항생제 활성 스펙트럼

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

동작 모드

protein synthesis | interferes

저장 온도

2-8°C

SMILES string

OS(O)(=O)=O.NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

InChI

1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1

InChI key

HIBICIOPDUTNRR-BOEHXBESSA-N

관련 카테고리

일반 설명

Chemical structure: aminoglycoside

애플리케이션

Amikacin is an aminoglycoside antibiotic commonly used in the treatment of drug-resistant mycobacteria . It is used to study organism-directed delivery of antibiotics as well as drug resistance .

생화학적/생리학적 작용

Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading.
Antibacterial spectrum: Gram-negative and gram-positive bacteria.

기타 정보

Aminoglycoside antibiotic. Derivative of kanamycin.
Keep container tightly closed in a dry and well-ventilated place.

품질

Amikacin:Sulfate ratio 1:1.8

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

A M Lovering et al.
The Journal of antimicrobial chemotherapy, 43(5), 719-721 (1999-06-26)
Antibiotic-free human serum was spiked with known concentrations of liposomal amikacin and assayed on the Abbott TDx System, using polarization fluoroimmuno assay (PFIA) kits from Abbott Laboratories, Oxis and Sigma. Although all three kits gave a linear response, the Abbott
Justin R Lenhard et al.
Diagnostic microbiology and infectious disease, 98(1), 115080-115080 (2020-07-04)
The objective of this study was to utilize a co-culture hollow-fiber infection model (HFIM) to characterize the interplay between a small, difficult-to-detect, New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae (NDM-Kp) minor population and a larger K. pneumoniae carbapenemase (KPC)-producing K. pneumoniae population
Targeted Delivery of Amikacin into Granuloma.
Ana Montes-Worboys, et al.
American Journal of Respiratory Cell and Molecular Biology, 182, 1546-1553 (2010)
Luiz Fernando Feres et al.
Animal reproduction science, 193, 165-170 (2018-04-22)
The aim of the present study was to evaluate the likelihood of pregnancy of in vitro-produced (IVP) embryos from batches with distinct relative efficiencies. Data were retrospectively analyzed from 605 transvaginal ultrasonic-guided follicle aspiration sessions (OPU) followed by in vitro
Lejla Imamovic et al.
Cell, 172(1-2), 121-134 (2018-01-09)
Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated

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