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Merck
모든 사진(1)

문서

A1709

Sigma-Aldrich

Adrenocorticotropic Hormone Fragment 1-10 human, rat

≥97% (HPLC)

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C59H78N16O16S
CAS Number:
2791-05-1
Molecular Weight:
1299.41
MDL number:
MFCD00133029
UNSPSC 코드:
12352200
PubChem Substance ID:
24890477

분석

≥97% (HPLC)

형태

powder

색상

white

UniProt 수납 번호

P01189
P01194

저장 온도

−20°C

SMILES string

CSCCC(NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CO)C(=O)NC(CCC(O)=O)C(=O)NC(Cc2cnc[nH]2)C(=O)NC(Cc3ccccc3)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NCC(O)=O

InChI

1S/C59H78N16O16S/c1-92-21-19-42(70-58(91)47(30-77)75-56(89)43(71-50(83)38(60)29-76)23-33-13-15-36(78)16-14-33)54(87)69-41(17-18-48(79)80)53(86)74-46(25-35-27-63-31-67-35)57(90)72-44(22-32-8-3-2-4-9-32)55(88)68-40(12-7-20-64-59(61)62)52(85)73-45(51(84)66-28-49(81)82)24-34-26-65-39-11-6-5-10-37(34)39/h2-6,8-11,13-16,26-27,31,38,40-47,65,76-78H,7,12,17-25,28-30,60H2,1H3,(H,63,67)(H,66,84)(H,68,88)(H,69,87)(H,70,91)(H,71,83)(H,72,90)(H,73,85)(H,74,86)(H,75,89)(H,79,80)(H,81,82)(H4,61,62,64)

InChI key

DIBOMWBTHPDGOJ-UHFFFAOYSA-N

유전자 정보

human ... POMC(5443)
rat ... Pomc(24664)

Amino Acid Sequence

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly

애플리케이션

Adrenocorticotropic Hormone Fragment 1-10 [ACTH(1-10)] is used as a model peptide to study the the suitability of various mimic structures to make micelle models of biological membranes.

생화학적/생리학적 작용

Facilitates avoidance acquisition. Lacks adrenocorticotropic activity.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

Tuck C Wong et al.
Journal of biomolecular structure & dynamics, 20(1), 39-57 (2002-07-30)
The structure and interactions of the 1-24 fragment of the adrenocorticotropin hormone, ACTH (1-24), with membrane have been studied by molecular dynamics (MD) simulation in an NPT ensembles in two explicit membrane mimics, a dodecylphosphocholine (DPC) micelle and a dimyristoylphosphatidylcholine
T Wymore et al.
Journal of biomolecular structure & dynamics, 18(3), 461-476 (2001-01-10)
ACTH (1-10), an adrenocorticotropin hormone fragment, was studied by molecular dynamics (MD) simulation in the NPT ensemble in an explicit sodium dodecylsulfate (SDS) micelle. Initially, distance restraints derived from NMR nuclear Overhauser enhancements were incorporated during the equilibration stage of
M D Gomar et al.
Experientia, 51(3), 209-212 (1995-03-15)
In this study, we examined the effect of intracerebroventricular (i.c.v) injection of melatonin and/or ACTH1-10 and ACTH4-10 on [3H]flunitrazepam binding sites in the cerebral cortex of hypophysectomized rats. Hypophysectomy increased the Bmax (maximum number of binding sites) of benzodiazepine (BNZ)
Molecular dynamics simulation of adrenocorticotropin (1-10) peptide in a solvated dodecylphosphocholine micelle.
Gao X, Wong TC.
Biopolymers, 58, 6430659-6430659 (2001)
M J Hoogduijn et al.
Biochemical and biophysical research communications, 290(2), 844-850 (2002-01-12)
The melanocortins are involved in the regulation of various cognitive and physiological processes such as learning, feeding, immune suppression, pigmentation, and sebum production. Five melanocortin receptors have been identified, of which the melanocortin 5 receptor (MC5R) has the most widespread

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