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Merck
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주요 문서

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83907

Sigma-Aldrich

Rifampicin

≥97.0% (HPLC)

동의어(들):

3-(4-Methylpiperazinyliminomethyl)rifamycin SV, Rifampin, Rifamycin AMP

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C43H58N4O12
CAS Number:
13292-46-1
Molecular Weight:
822.94
Beilstein:
5723476
EC Number:
236-312-0
MDL number:
MFCD00151389
UNSPSC 코드:
51101500
PubChem Substance ID:
57652978

분석

≥97.0% (HPLC)

형태

powder

색상

faintly red to very dark red

solubility

chloroform: 0.25 g/5mL

항생제 활성 스펙트럼

mycobacteria

동작 모드

protein synthesis | interferes

저장 온도

2-8°C

SMILES string

CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\C=N\N5CCN(C)CC5)c(O)c4c3C2=O

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

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일반 설명

Chemical structure: macrolide

애플리케이션

Rifampicin is used as a selective cytochrome P4503A4 inducer. Studies have shown that rifampicin inhibits African Swine Fever Virus replication in tissue culture and inhibits the induction of tyrosine aminotransferase by cortisol in rat hepatoma cells grown in culture .

생화학적/생리학적 작용

Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture. Store under inert gas.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302,H315,H319,H335,H362

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

A H Dardiri et al.
Infection and immunity, 4(1), 34-36 (1971-07-01)
Vaccinia virus and African swine fever virus are deoxyribonucleic acid viruses of cytoplasmic origin. The fact that rifampin inhibits the replication of the former virus led to an investigation of its effect on African swine fever virus. The virus used
Post-transcriptional inhibition of protein synthesis by rifampicin in rat hepatoma cells.
Albert Grossman and Amal Boctor
Life Sciences, 12, 289-295 (1973)
Sandra V Kik et al.
The Journal of infectious diseases, 211 Suppl 2, S58-S66 (2015-03-15)
The potential available market (PAM) for new diagnostics for tuberculosis that meet the specifications of the high-priority target product profiles (TPPs) is currently unknown. We estimated the PAM in 2020 in 4 high-burden countries (South Africa, Brazil, China, and India)
Samy Figueiredo et al.
Antimicrobial agents and chemotherapy, 53(6), 2657-2659 (2009-03-25)
Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of
Laurent Poirel et al.
Antimicrobial agents and chemotherapy, 55(2), 934-936 (2010-12-01)
Seven carbapenem-resistant NDM-1-positive Klebsiella pneumoniae isolates were recovered from patients hospitalized between 2007 and 2009 in different wards at a referral and tertiary care center in Nairobi. Most of the isolates were obtained from urine. All isolates carried the bla(NDM-1)
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