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Merck
모든 사진(1)

문서

48488

Sigma-Aldrich

Sodium (±)-homocitrate tribasic

동의어(들):

2-Hydroxy-1,2,4-butanetricarboxylic acid trisodium salt, Trisodium homocitrate

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About This Item

실험식(Hill 표기법):
C7H7Na3O7
Molecular Weight:
272.10
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.25

불순물

≤15.0% water

SMILES string

[Na+].[Na+].[Na+].OC(CCC([O-])=O)(CC([O-])=O)C([O-])=O

InChI

1S/C7H10O7.3Na/c8-4(9)1-2-7(14,6(12)13)3-5(10)11;;;/h14H,1-3H2,(H,8,9)(H,10,11)(H,12,13);;;/q;3*+1/p-3

InChI key

SNTBDRNHMPWDFS-UHFFFAOYSA-K

애플리케이션

Sodium (±)-homocitrate tribasic may be used in studies of formation and function of the iron-molybdenum cofactor (FeMo-co) which contains 7Fe, 9S, Mo, R-homocitrate. FeMo-co is essential for nitrogen fixation by nitrogenous organisms.

생화학적/생리학적 작용

Component of the iron-molybdenum cofactor of nitrogenases , essential isomerization of homocitrate via homoaconitate to homoisocitrate, homocitrate accumulation seems to act as a sensor of lysine-pathway distress.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

T R Hoover et al.
Nature, 329(6142), 855-857 (1987-10-04)
Nitrogenase catalyses the ATP-dependent reduction of N2 to NH3, and is composed of two proteins, dinitrogenase (MoFe protein or component I) and dinitrogenase reductase (Fe protein or component II). Dinitrogenase contains a unique prosthetic group (iron-molybdenum cofactor, FeMoco) comprised of
T R Hoover et al.
Biochemistry, 28(7), 2768-2771 (1989-04-04)
When apodinitrogenase (lacking FeMo-co) was activated with FeMo-co synthesized in vitro in the presence of 3H-labeled homocitrate, label was incorporated into dinitrogenase. The physical association of the label with FeMo-co was demonstrated by reisolation and purification of the cofactor from
L Ma et al.
The Journal of biological chemistry, 269(27), 18007-18015 (1994-07-08)
Here we report the large scale isolation and characterization of a species, designated MoFe cluster, that exhibits an S = 3/2 EPR signal, and the comparison of this entity to isolated FeMo cofactor in N-methylformamide and to the active site
J Imperial et al.
Biochemistry, 28(19), 7796-7799 (1989-09-19)
(R)-2-Hydroxy-1,2,4-butanetricarboxylic acid [(R)-homocitrate] has been has been recently reported to be an integral constituent of the otherwise thought to be inorganic iron-molybdenum cofactor of dinitrogenase [Hoover, T.R., Imperial, J., Ludden, P.W., & Shah, V.K. (1989) Biochemistry 28,2768-2771]. Different organic acids
Leonardo Curatti et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(45), 17626-17631 (2007-11-06)
Biological nitrogen fixation, the conversion of atmospheric N2 to NH3, is an essential process in the global biogeochemical cycle of nitrogen that supports life on Earth. Most of the biological nitrogen fixation is catalyzed by the molybdenum nitrogenase, which contains

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