추천 제품
생물학적 소스
mouse
Quality Level
100
500
결합
unconjugated
항체 형태
culture supernatant
항체 생산 유형
primary antibodies
클론
SX53G8, monoclonal
설명
For In Vitro Diagnostic Use in Select Regions (See Chart)
양식
buffered aqueous solution
종 반응성
human
포장
vial of 0.1 mL concentrate (427M-94)
vial of 0.5 mL concentrate (427M-95)
bottle of 1.0 mL predilute (427M-97)
vial of 1.0 mL concentrate (427M-96)
bottle of 7.0 mL predilute (427M-98)
제조업체/상표
Cell Marque®
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
동형
IgG1κ
제어
tonsil
배송 상태
wet ice
저장 온도
2-8°C
시각화
nuclear
유전자 정보
rat ... Cdkn1B(83571)
일반 설명
p27 is a cyclin-dependent kinase inhibitor which regulates progression from G1 to S phase by binding and inhibiting cyclin-dependent kinases. Low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, small breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, lymph node metastases in Papillary carcinoma of the Thyroid, and more aggressive phenotype in carcinoma of the cervix.
품질
 IVD |  IVD |  IVD |  RUO |
결합
p27Kip1 Positive Control Slides, Product No. 427S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
물리적 형태
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
제조 메모
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
기타 정보
For Technical Service please contact: 800-665-7284 or email: [email protected]
법적 정보
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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시험 성적서(COA)
Lot/Batch Number
P Tan et al.
Cancer research, 57(7), 1259-1263 (1997-04-01)
Breast carcinomas < or = 1 cm in size (T1a,b) are being detected more frequently as a result of screening. Because traditional prognostic parameters are either lacking (tumor size) or rare (nodal metastases), a marker(s) is needed to identify the
V Esposito et al.
Cancer research, 57(16), 3381-3385 (1997-08-15)
Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. We investigated p27 protein expression in a series of 108 non-small
Carolina Armengol et al.
Journal of hepatology, 38(5), 591-597 (2003-04-26)
Alterations in p27(Kip1) (p27) and cyclin E (cycE) expression are found in tumors and are related to poor prognosis. This study assesses the role of these cell cycle regulators in the development of recurrence after surgical resection in 46 cirrhotic
A Haitel et al.
Urology, 58(3), 477-481 (2001-09-11)
To determine whether p21, p27, and pRb can predict disease progression in clear cell renal cell carcinoma. The expression of three negative regulators of the cell cycle, the retinoblastoma gene product (pRb), the WAF1/Cip1 gene product (p21), and the Kip1
Toshiro Migita et al.
Cancer, 94(4), 973-979 (2002-03-29)
Proliferative activity in tumors depends on regulation of the cell cycle. p27(Kip1) (p27) plays a pivotal role as a negative regulator of the cell cycle. A decrease in p27 expression has been reported in many kinds of tumors, but little
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