42129
Lathosterolamide MGI-39
≥97.0% (HPLC)
동의어(들):
(3S,20S)-20-N-(2-Methylpropyl)carbamoylpregn-7-en-3β-ol, (3S,20S)-3β-Hydroxy-N-(2-methylpropyl)-7-pregnene-20-carboxamide, Lathosterol Oxidase Inhibitor
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C26H43NO2
CAS Number:
Molecular Weight:
401.63
MDL number:
UNSPSC 코드:
12352204
PubChem Substance ID:
생물학적 소스
synthetic
분석
≥97.0% (HPLC)
양식
crystals and lumps
저장 온도
2-8°C
SMILES string
CC(C)CNC(=O)[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C26H43NO2/c1-16(2)15-27-24(29)17(3)21-8-9-22-20-7-6-18-14-19(28)10-12-25(18,4)23(20)11-13-26(21,22)5/h7,16-19,21-23,28H,6,8-15H2,1-5H3,(H,27,29)/t17-,18-,19-,21+,22-,23-,25-,26+/m0/s1
InChI key
HUMXZYXRXDDZOG-LFZVSNMSSA-N
생화학적/생리학적 작용
Lathosterolamide MGI-39 is an inhibitor of lathosterol oxidase which converts 5-α-cholest-7-en-3-β-ol to cholesta-5,7-dien-3β-ol.
포장
Bottomless glass bottle. Contents are inside inserted fused cone.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
가장 최신 버전 중 하나를 선택하세요:
Ken'ichi Hagiwara et al.
Biological & pharmaceutical bulletin, 30(4), 835-838 (2007-04-06)
In prion diseases, the normal cellular form of prion protein (PrP(C)) is converted into the disease-associated isoforms (PrP(Sc)) which accumulate in the infected tissues. Although the precise mechanism of this conversion remains unsolved, drugs of various categories have been reported
Carlos Fernández et al.
Journal of lipid research, 46(5), 920-929 (2005-02-03)
Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement, cholesterol is essential in cell proliferation and other cell processes. The aim of the present study was to elucidate the stringency
Carolina C Sánchez-Martín et al.
Cancer research, 67(7), 3379-3386 (2007-04-06)
Cholesterol metabolism is particularly active in malignant, proliferative cells, whereas cholesterol starvation has been shown to inhibit cell proliferation. Inhibition of enzymes involved in cholesterol biosynthesis at steps before the formation of 7-dehydrocholesterol has been shown to selectively affect cell
Martin Giera et al.
Steroids, 73(3), 299-308 (2008-01-01)
Inhibition of cholesterol biosynthesis offers the opportunity for treatment of cardiovascular diseases. Numerous enzymes are involved in the post-squalene part of this biosynthesis, and selective inhibitors for almost all of the enzymes involved there have been described in literature. The
Ralf Klingenstein et al.
Journal of neurochemistry, 98(3), 748-759 (2006-06-06)
Prion diseases are invariably fatal, neurodegenerative diseases transmitted by an infectious agent, PrPSc, a pathogenic, conformational isoform of the normal prion protein (PrPC). Heterocyclic compounds such as acridine derivatives like quinacrine abolish prion infectivity in a cell culture model of
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