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Merck
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문서

PHR1549

Supelco

1,4-Dioxane

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

1,4-Dioxane, Diethylene oxide, Dioxane

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About This Item

실험식(Hill 표기법):
C4H8O2
CAS Number:
Molecular Weight:
88.11
Beilstein:
102551
EC Number:
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to USP 1601521

vapor density

3 (vs air)

vapor pressure

27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

CofA

current certificate can be downloaded

autoignition temp.

356 °F

expl. lim.

22 %

포장

ampule of 3x1.2 mL each

기술

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.422 (lit.)

bp

100-102 °C (lit.)

mp

10-12 °C (lit.)

density

1.034 g/mL at 25 °C (lit.)

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-30°C

SMILES string

C1COCCO1

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

InChI key

RYHBNJHYFVUHQT-UHFFFAOYSA-N

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일반 설명

1,4-Dioxane belongs to the class of volatile organic compounds (VOCs).
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

애플리케이션

1,4-Dioxane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk pharmaceuticals, and cosmetic raw materials and finished products by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

분석 메모

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

기타 정보

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

각주

To see an example of a Certificate of Analysis for this material enter LRAC0289 in the slot below. This is an example certificate only and may not be the lot that you receive.

추천 제품

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

픽토그램

FlameHealth hazardExclamation mark

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

표적 기관

Respiratory system

보충제 위험성

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point (°F)

51.8 °F - closed cup

Flash Point (°C)

11 °C - closed cup


Choose from one of the most recent versions:

시험 성적서(COA)

Lot/Batch Number

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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이미 열람한 고객

A capillary gas chromatographic procedure for the analysis of nine common residual solvents in water-insoluble bulk pharmaceuticals
Li QC, et al.
Journal of Chromatographic Science, 36(3), 119-124 (1998)
Occurrence of 1, 4-dioxane in cosmetic raw materials and finished cosmetic products
Black RE, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 84(3), 666-670 (2001)
Establishment of a knowledge base for prescreening residual solvents in pharmaceuticals
Qin L, et al.
Chromatographia, 59(7-8), 475-480 (2004)
Simultaneous determination of 22 volatile organic compounds, methyl-tert-butyl ether, 1, 4-dioxane, 2-methylisoborneol and geosmin in water by headspace solid phase microextraction-gas chromatography-mass spectrometry
Nakamura S and Daishima S
Analytica Chimica Acta, 548(1-2), 79-85 (2005)
Joshua J Pacheco et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8363-8367 (2014-06-10)
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