G5882

Glutaraldehyde solution

Grade I, 25% in H₂O, specially purified for use as an electron microscopy fixative

• 동의어(들): Glutaric dialdehyde solution, Pentane-1,5-dial
• Linear Formula: OHC(CH₂)₃CHO
• CAS Number: 111-30-8
• Molecular Weight: 100.12
• Beilstein: 605390
• MDL number: MFCD00007025
• UNSPSC 코드: 12352114
• PubChem Substance ID: 24895235
• NACRES: NA.21

속성

• Quality Level: 300
• 유형: Grade I
• 형태: liquid
• 농도: 25% in H₂O
• 기술: electron microscopy: suitable (fixative); electron microscopy: suitable
• 색상: colorless
• 유용한 pH 범위: 2.9
• mp: -10 °C ((14 °F ))
• solubility: water: soluble at 20 °C
• 응용 분야: cell analysis
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [H]C(CCCC([H])=O)=O
• InChI: 1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
• InChI key: SXRSQZLOMIGNAQ-UHFFFAOYSA-N

설명

일반 설명

Glutaraldehyde (Glutaric dialdehyde, Pentane-1,5-dial) is an aliphatic dialdehyde widely utilized as a versatile biochemical reagent. Glutaraldehyde solutions contain both monomers and polymers with the difference in their fixation properties. Its applications include serving as a protein crosslinker, facilitating enzyme immobilization in microscopy, histochemistry, and cytochemistry. This compound acts as an amine-reactive homobifunctional crosslinker and a cell fixative before SDS-PAGE, staining, or electron microscopy, making it suitable for diverse morphological studies.
Glutaraldehyde efficiently crosslinks amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it has been used in certain reactions to directly couple biotin hydrazides to nucleic acids, suggesting potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. In histology studies, Glutaraldehyde is employed to preserve tissue sections, preparing them for closer examination.

애플리케이션

Glutaraldehyde solution has been used:

• to fix the blood samples for scanning electron microscopy (SEM)
• to fix scaffold pieces for SEM analysis
• in drug treatments to treat K562 (leukemia) cells to permanently cross-link cell components

생화학적/생리학적 작용

Glutaraldehyde can be used in biomedical research to fix cells. It can also be used as a tool to investigate healthy and pathologic red blood cells. Medical equipment like spirometry tubing, endoscopes, dialyzers, hemodialysis proportioning and dialysate delivery systems, endocavitary probes, transducers, anesthesia and respiratory therapy equipment, and reuse of laparoscopic disposable plastic trocars can be disinfected with glutaraldehyde.

특징 및 장점

• Versatile and adaptable for wide variety of research applications
• Ready-made solution reduces the need for preparation time

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Recommended for techniques demanding high purity.

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H302 + H332,H314,H317,H334,H335,H410
• 예방조치 성명서: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter