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Merck
모든 사진(1)

문서

36687

Supelco

4-Aminopyridine

PESTANAL®, analytical standard

동의어(들):

4-Pyridinamine, 4-Pyridylamine, 4AP, Fampridine

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About This Item

실험식(Hill 표기법):
C5H6N2
CAS Number:
Molecular Weight:
94.11
Beilstein:
105782
EC Number:
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Grade

analytical standard

Quality Level

제품 라인

PESTANAL®

유통기한

limited shelf life, expiry date on the label

기술

HPLC: suitable
gas chromatography (GC): suitable

bp

273 °C (lit.)

mp

155-158 °C (lit.)

응용 분야

agriculture
environmental

형식

neat

SMILES string

Nc1ccncc1

InChI

1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)

InChI key

NUKYPUAOHBNCPY-UHFFFAOYSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

4-Aminopyridine is a small molecule potassium channel blocker, which stimulates the release of glutamate from nerve terminals and induces seizures. It can also be used as a drug that aims to improve ambulatory impairment, a major symptom of multiple sclerosis disease.

애플리케이션

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

법적 정보

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

픽토그램

Skull and crossbonesCorrosionEnvironment

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

312.8 °F

Flash Point (°C)

156 °C

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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시험 성적서(COA)

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이미 열람한 고객

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1 of 1

Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats
Sadeghnia RH, et al.
Iranian Journal of Basic Medical Sciences, 20, 588-588 (2017)
4-Aminopyridine ameliorates experimental autoimmune neuritis in Lewis rats
Moriguchi K, et al.
Journal of Neuroimmunology, 305, 72-74 (2017)
Massimo Avoli et al.
Neurobiology of disease, 52, 168-176 (2012-12-29)
4-Aminopyridine (4AP, 50 μM) induces interictal- and ictal-like discharges in brain slices including parahippocampal areas such as the entorhinal cortex (EC) but the relation between these two types of epileptiform activity remains undifined. Here, by employing field potential recordings in
R I Westphalen et al.
British journal of anaesthesia, 110(4), 592-599 (2012-12-06)
Presynaptic effects of general anaesthetics are not well characterized. We tested the hypothesis that isoflurane exhibits transmitter-specific effects on neurotransmitter release from neurochemically and functionally distinct isolated mammalian nerve terminals. Nerve terminals from adult male rat brain were prelabelled with
Laura Uva et al.
Epilepsia, 54(4), 605-615 (2013-03-20)
The study of the interactions leading to network- or region-specific propagation of seizures is crucial to understand ictogenesis. We have recently found that systemic (arterial) application of the potassium channel blocker, 4-aminopyridine (4AP), induces different and independent seizure activities in

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