01760595

Apigenin

primary reference standard

• 동의어(들): 4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
• 실험식(Hill 표기법): C₁₅H₁₀O₅
• CAS Number: 520-36-5
• Molecular Weight: 270.24
• Beilstein: 262620
• EC Number: 208-292-3
• MDL number: MFCD00006831
• UNSPSC 코드: 85151701
• PubChem Substance ID: 329747355
• NACRES: NA.24

속성

• Grade: primary reference standard
• 유통기한: limited shelf life, expiry date on the label
• 제조업체/상표: HWI
• mp: >300 °C (lit.)
• 응용 분야: food and beverages
• SMILES string: Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• InChI key: KZNIFHPLKGYRTM-UHFFFAOYSA-N

설명

일반 설명

Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor.

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

애플리케이션

It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats.

생화학적/생리학적 작용

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G₂/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

기타 정보

This compound is commonly found in plants of the genus: achillea mentha pimpinella primula salvia silybum thymus

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3