MABS497

Anti-Cytochrome P450 26B1 Antibody, clone 4B7.2

clone 4B7.2, from mouse

• 동의어(들): Cytochrome P450 26B1, Cytochrome P450 26A2, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450, subfamily XXVIB, polypeptide 1, Cytochrome P450RAI-2, Retinoic acid-metabolizing cytochrome
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 4B7.2, monoclonal
• 종 반응성: mouse, rat, human
• 기술: immunohistochemistry: suitable (paraffin); western blot: suitable
• 동형: IgG2aκ
• NCBI 수납 번호: NP_063938
• UniProt 수납 번호: Q9NR63
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CYP26B1(56603)

설명

일반 설명

Cytochrome P450 26B1 (UniProt Q9NR63; also known as Cytochrome P450 26A2, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450, subfamily XXVIB, polypeptide 1, Cytochrome P450RAI-2, Retinoic acid-metabolizing cytochrome) is encoded by the CYP26B1 (also known as CYP26A2, P450RAI2, RHFCA) gene (Gene ID 56603) in human. Cytochromes P450 (CYP) proteins are primarily membrane-associated oxidases located either in the inner membrane of mitochondria or in the endoplasmic reticulum. In addition to processing endogenous substrates, CYPs also metabolize exogenous drugs and potentially toxic chemicals. The human CYP superfamily consists of 57 genes and more than 59 pseudogenes divided into 18 families and 43 subfamilies. The CYP26 subfamily of enzymes (CYP26A1, CYP26B1/CYP26A2, CYP26C1) are retinoic acid hydroxylases responsible for the inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid. CYP26B1 is overexpressed in colorectal cancer (CRC) cells, high CYP26B1 expression level in CRC patients is associated with poor prognosis. CYP26B1 mutations are found in radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA), a disease characterized by craniofacial malformations, occipital encephalocele, radiohumeral fusions, oligodactyly, advanced osseous maturation, and calvarial mineralization defects.

특이성

Expected to react with all three spliced isoforms of human CYP26B1 reported by UniProt (Q9NR63).

면역원

Epitope: Internal (C-terminal half).

GST-tagged recombinant internal fragment from the C-terminal half of human Cytochrome P450 26B1.

애플리케이션

Anti-Cytochrome P450 26B1 Antibody, clone 4B7.2 is an antibody against Cytochrome P450 26B1 for use in Western Blotting, Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Cytochrome P450 26B1 in human brain, mouse brain, and rat cerebellum tissue.

Research Category
Signaling

Research Sub Category
Toxicology & Drug Resistance

품질

Evaluated by Western Blotting in mouse brain tissue microsomal lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Cytochrome P450 26B1 in 10 µg of mouse brain tissue microsomal lysate.

표적 설명

~57 kDa observed. 57.51 kDa (isoform 1), 49.01 kDa (isoform 2), and 55.76 kDa (isoform 3) calculated. Uncharacterized band(s) may appear in some lysates.

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable