MABF248

Anti-SLFN11 Antibody, clone 4G9

clone 4G9, 0.25 mg/mL, from mouse

• 동의어(들): Schlafen family member 11, SLFN11
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 4G9, monoclonal
• 종 반응성: human
• 농도: 0.25 mg/mL
• 기술: immunoprecipitation (IP): suitable; western blot: suitable
• 동형: IgMκ
• NCBI 수납 번호: NP_001098057
• UniProt 수납 번호: Q7Z7L1
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SLFN11(91607)

설명

일반 설명

SLFN11, also known as Schlafen family member 11, and encoded by the gene SLFN11, is an interesting protein that is part of our innate defense against retroviruses. The protein is induced by interferon and acts to inhibit the translation of retrovirus specific proteins. SLFN11 also plays a role in cell cycle arrest and apoptosis induction, particularly in response to DNA damage. SLFN11 is localized to the nucleus and is widely expressed and up regulated in various cancers including ovarian and adenocarcinomas, and recent work suggests that SLFN11 may behave as a biomarker for prediction of response to DNA-damaging agents in the clinical setting.

면역원

Recombinant protein corresponding to human SLFN11.

애플리케이션

Anti-SLFN11 Antibody, clone 4G9 is an antibody against SLFN11 for use in western blotting & IP.

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

Western Blotting/Immunoprecipitation Analysis: A representative lot immunoprecipitated SLFN11 from transfected HEK293 cell lysates. The same lot was used to detect SLFN11 in Western Blotting (Prof. Michael David, University of California, San Diego.).

Electron Mobility Shift Assay Analysis: A representative lot from an independent laboratory detected SLFN11 bound t-RNA (Li, M., et al. (2012). Nature. 491(7422):125-128.).

품질

Evaluated by Western Blotting in HEK293T cell lysates transfected with SLFN11 or a negative control.

Western Blotting Analysis: A 1:500 dilution of this antibody detected SFN11 in HEK293T cell lysates transfected with SLFN11 and not in HEK293T cell lysates transfected with a negative control.

표적 설명

~100 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

물리적 형태

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable