MABE989

Anti-Homeodomain-only Protein Antibody, clone 15C1.1

clone 15C1.1, from mouse

• 동의어(들): Lung cancer-associated Y protein, Homeodomain-only Protein, Not expressed in choriocarcinoma protein 1, Odd homeobox protein 1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.43
• 클론: 15C1.1, monoclonal
• application: WB
• 종 반응성: mouse
• 기술: western blot: suitable

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 15C1.1, monoclonal
• 종 반응성: mouse
• 종 반응성(상동성에 의해 예측): human (based on 100% sequence homology)
• 기술: western blot: suitable
• 동형: IgG2bκ
• NCBI 수납 번호: NP_001138931
• UniProt 수납 번호: Q9BPY8
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... HOPX(84525)

설명

일반 설명

Homeodomain-only protein (UniProt Q9BPY8; also known as Lung cancer-associated Y protein, Not expressed in choriocarcinoma clone 1, Not expressed in choriocarcinoma protein 1, Odd homeobox 1 protein, Odd homeobox protein 1) is encoded by the HOPX (also known as CAMEO, HOD, HOP, LAGY, NECC1, OB1, SMAP31, TOTO) gene (Gene ID 84525) in human. Human and mouse HOPX proteins share 92% identity, they contain homeobox-like domain but lack sequence motif required for DNA binding. HOPX is highly expressed in the developing heart, where its expression is dependent on the cardiac-restricted homeobox protein, Nkx2.5. HOPX physically interacts with serum responsive factor (SRF) and inhibits SRF-dependent transcription by inhibiting SRF binding to DNA and by recruiting histone deacetylase (HDAC) activity. HOPX is reported to play a critical role in the differentiation of various cells such as myoblasts, trophoblasts, keratinocytes, T cells, and lung alveolar cells. HOPX was initially reported as a differentiation marker and is expressed in various normal tissues, and HOPX expression is markedly suppressed in a subset of cancers.

특이성

Expected to react with spliced isoforms 1, 3, and 4. Reactivity toward isoform 2 has not been determined.

면역원

GST-tagged recombinant protein corresponding to human Homeodomain-only Protein.

애플리케이션

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Nuclear Receptors

This Anti-Homeodomain-only Protein Antibody, clone 15C1.1 is validated for use in Western Blotting for the detection of Homeodomain-only Protein.

품질

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Homeodomain-only Protein in 10 µg of mouse lung tissue lysate.

표적 설명

~10 kDa observed. Uncharacterized band(s) may appear in some lysates.

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable