MABE461
Anti-CRTC1 Antibody/TORC-1, clone 5F3.1
clone 5F3.1, from mouse
동의어(들):
CREB-regulated transcription coactivator 1, Mucoepidermoid carcinoma translocated protein 1, Transducer of regulated cAMP response element-binding protein 1, TORC-1, Transducer of CREB protein 1, CRTC1/TORC-1
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모든 사진(6)
About This Item
UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
생물학적 소스
mouse
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
5F3.1, monoclonal
종 반응성
mouse, rat, human
기술
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
동형
IgG2aκ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... CRTC1(23373)
일반 설명
CREB-regulated transcription coactivator 1 (UniProt Q6UUV9; also known as Mucoepidermoid carcinoma translocated protein 1, TORC-1, Transducer of CREB protein 1, Transducer of regulated cAMP response element-binding protein 1) is encoded by the CRTC1 (also known as KIAA0616, MECT1, TORC1, WAMTP1) gene (Gene ID 23373) in human. CRTC1 belongs to a family of glycosylated Ser/Thr-rich phosphoproteins that bind the basic leucine zipper (bZIP) region of Ca2+/cAMP-responsive element-binding protein (CREB) and function as CREB coactivators. CRTCs participate in CREB-mediated transcriptions of both canonical cellular cAMP response elements (CREs) and the non-canonical viral CREs. CRTC1, specifically, is involved in CREB-mediated transcription of various neuronal immediate early genes (IEGs) as well as CREB-dependent hepatitis B virus (HBV) replication.
특이성
Expected to react with all three human spliced isoforms
면역원
Epitope: Internal (N-terminal half)
GST-tagged recombinant protein corresponding to human CRTC1/TORC-1 sequence within the N-terminal half..
애플리케이션
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Nuclear Receptors
Nuclear Receptors
This Anti-CRTC1 Antibody/TORC-1, clone 5F3.1 is validated for use in Western Blotting, Immunohistochemistry, Immunoprecipitation for the detection of CRTC1.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected CRTC1/TORC-1 in 10 µg of mouse hypothalamus tissue lysate.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected CRTC1/TORC-1 in human cerebral cortex, rat cerebral cortex, human cerebellum, and rat cerebellum tissue.
Immunoprecipitation Analysis: A representative lot immunoprecipitated endogenous CRTC1/TORC-1 from mouse hippocampus tissue lysates, as well as exogenously expressed murine CRTC1/TORC-1, but not CRTC2/TORC-2, from lysates of transfected HEK293 cells (Courtesy of Dr. Carlos A. Saura , Universitat Autònoma de Barcelona, Spain).
Western Blotting Analysis: A representative lot detected endogenous CRTC1/TORC-1 in human, mouse, and rat hippocampus tissue lysates, as well as exogenously expressed murine CRTC1/TORC-1 in lysates from transfected HEK293 cells (Courtesy of Dr. Carlos A. Saura , Universitat Autònoma de Barcelona, Spain).
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected CRTC1/TORC-1 in human cerebral cortex, rat cerebral cortex, human cerebellum, and rat cerebellum tissue.
Immunoprecipitation Analysis: A representative lot immunoprecipitated endogenous CRTC1/TORC-1 from mouse hippocampus tissue lysates, as well as exogenously expressed murine CRTC1/TORC-1, but not CRTC2/TORC-2, from lysates of transfected HEK293 cells (Courtesy of Dr. Carlos A. Saura , Universitat Autònoma de Barcelona, Spain).
Western Blotting Analysis: A representative lot detected endogenous CRTC1/TORC-1 in human, mouse, and rat hippocampus tissue lysates, as well as exogenously expressed murine CRTC1/TORC-1 in lysates from transfected HEK293 cells (Courtesy of Dr. Carlos A. Saura , Universitat Autònoma de Barcelona, Spain).
품질
Evaluated by Western Blotting in mouse cerebellum tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected CRTC1/TORC-1 in 10 µg of mouse cerebellum tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected CRTC1/TORC-1 in 10 µg of mouse cerebellum tissue lysate.
표적 설명
~68 kDa observed
물리적 형태
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
기타 정보
Concentration: Please refer to lot specific datasheet.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
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