MABC1031

Anti-TNFSF13 (APRIL) Antibody, clone A3D8

clone A3D8, from hamster(Armenian)

• 동의어(들): A proliferation-inducing ligand, APRIL, CD256, TALL-2
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.43

속성

• 생물학적 소스: hamster (Armenian)
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: A3D8, monoclonal
• 종 반응성: human, mouse
• 기술: flow cytometry: suitable
• 동형: IgG
• NCBI 수납 번호: NP_076006
• UniProt 수납 번호: Q9D777
• 배송 상태: ambient
• 타겟 번역 후 변형: unmodified
• 유전자 정보: mouse ... Tnfsf13(69583)

설명

일반 설명

Tumor necrosis factor ligand superfamily member 13 (UniProt: Q9D777; also known as A proliferation-inducing ligand; APRIL; CD256) is encoded by the Tnfsf13 (also known as APRIL) gene (Gene ID: 69583) in mouse. APRIL is a secreted cytokine of the tumor necrosis family and is present in T cells, B cells, dendritic cells, monocytes, and macrophages. April exists as a functional homotrimer, but can form functional heterotrimers with B cell activating factor (BAFF). APRIL stimulates T and B cell proliferation and it exerts T and B cell regulatory effects by binding to TNFRSF17 (BCMA) and TNFRSF13B (TACI) receptors. It is also involved in monocyte/macrophage-mediated immunological processes. It also plays a role in the regulation of tumor cell growth and can induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. APRIL can serve as as a potential biomarker and its serum levels are shown to be elevated for certain cancers and expression levels elevated in cancer tissues.

특이성

Clone A3D8 detects TNFSF13/APRIL in human peripheral blood mononuclear cells (PBMC).

면역원

A full length recombinant fusion protein of murine maltose binding protein (MBP) and soluble APRIL.

애플리케이션

Detect TNFSF13 using this armenian hamster monoclonal Anti-TNFSF13 (APRIL) antibody, clone A3D8, Cat. No. MABC1031, validated for use in Flow Cytometry.

Flow Cytometry Analysis: 1 µg of this antibody from a representative lot detected TNFSF13 in one million RAW264.7 cells.

Research Category
Apoptosis & Cancer

품질

Evaluated by Flow Cytometry in human PBMC cells.

Flow Cytometry Analysis: 1 µg of this antibody detected TNFSF13 in human PBMC cells.

표적 설명

26.89 kDa calculated.

물리적 형태

Format: Purified

Protein G purified

Purified armenian hamster monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2