추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
HA5, monoclonal
종 반응성
pig, human
제조업체/상표
Chemicon®
기술
flow cytometry: suitable
immunoprecipitation (IP): suitable
동형
IgG2bκ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... ITGA5(3678)
관련 카테고리
특이성
Reacts with the fibronectin receptor VLA-5 (alpha-5beta-1) integrin complex.
애플리케이션
Anti-Integrin α5β1 Antibody, clone HA5 detects level of Integrin α5β1 & has been published & validated for use in FC & IP.
Immunoprecipitation of VLA-5 integrins from lysate of 10E6 cell equivalent requires 2 μg of MAB1999.
Flow cytometry: 10 μg/mL
Does not detect VLA-5 by Western blot.
MAB1999 does not affect VLA-5 mediated cell adhesion to fibronectin.
Optimal working dilutions must be determined by end user.
Flow cytometry: 10 μg/mL
Does not detect VLA-5 by Western blot.
MAB1999 does not affect VLA-5 mediated cell adhesion to fibronectin.
Optimal working dilutions must be determined by end user.
물리적 형태
Format: Purified
Purified immunoglobulin from Protein A chromatography. Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl, 0.1% sodium azide.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Yuya Sato et al.
The Journal of biological chemistry, 284(18), 11873-11881 (2009-03-12)
Recently we reported that N-glycans on the beta-propeller domain of the integrin alpha5 subunit (S-3,4,5) are essential for alpha5beta1 heterodimerization, expression, and cell adhesion. Herein to further investigate which N-glycosylation site is the most important for the biological function and
Ingrid Burvenich et al.
Molecular cancer therapeutics, 7(12), 3771-3779 (2008-12-17)
This study identifies and characterizes the antigen recognized by monoclonal antibody (mAb) 14C5. We compared the expression of antigen 14C5 with the expression of eight integrin subunits (alpha1, alpha2, alpha3, alphav, beta1, beta2, beta3, and beta4) and three integrin heterodimers
U Ruth Michaelis et al.
Circulation research, 112(6), 924-934 (2013-01-31)
Polarity proteins are involved in the apico-basal orientation of epithelial cells, but relatively little is known regarding their function in mesenchymal cells. We hypothesized that polarity proteins also contribute to endothelial processes like angiogenesis. Screening of endothelial cells revealed high
N-glycosylation of the beta-propeller domain of the integrin alpha5 subunit is essential for alpha5beta1 heterodimerization, expression on the cell surface, and its biological function.
Isaji, T; Sato, Y; Zhao, Y; Miyoshi, E; Wada, Y; Taniguchi, N; Gu, J
The Journal of Biological Chemistry null
Qinglei Hang et al.
The Journal of biological chemistry, 290(49), 29345-29360 (2015-10-21)
Integrin α5β1-mediated cell adhesion regulates a multitude of cellular responses, including cell proliferation, survival, and cross-talk between different cellular signaling pathways. Integrin α5β1 is known to convey permissive signals enabling anchorage-dependent receptor tyrosine kinase signaling. However, the effects of integrin
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