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Merck
모든 사진(1)

주요 문서

DR1002

Sigma-Aldrich

PhosphoDetect Anti-ATM (pSer¹⁹⁸¹) Mouse mAb (10H11.E12)

liquid, clone 10H11.E12, Calbiochem®

동의어(들):

Anti-Ataxia Telangiectasia, Phospho-Specific (Ser¹⁹⁸¹)

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About This Item

UNSPSC 코드:
12352203

생물학적 소스

mouse

Quality Level

항체 생산 유형

primary antibodies

클론

10H11.E12, monoclonal

양식

liquid

포함

≤0.1% sodium azide as preservative

종 반응성

human, mouse

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
avoid repeated freeze/thaw cycles

동형

IgG1

배송 상태

wet ice

저장 온도

−20°C

일반 설명

Protein G purified mouse monoclonal antibody. Recognizes the ~370 kDa ATM protein phosphorylated at Ser1981.
Recognizes the ~370 kDa ATM protein phosphorylated on Ser1981 in camptothecin-treated HeLa cells. Sold under license of U.S. Patent 7,108,992.
This PhosphoDetect Anti-ATM (pSer¹⁹⁸¹) Mouse mAb (10H11.E12) is validated for use in Immunoblotting, Immunocytochemistry for the detection of ATM (pSer¹⁹⁸¹).

면역원

Human
a synthetic phosphopeptide (SLAFEEGpSQSTTISS) corresponding to amino acids 1974-1988 surrounding the Ser¹⁹⁸¹ phosphorylation site of human ATM

애플리케이션





Immunoblotting (0.5 g/ml)
Immunocytochemistry (1.5 g/ml)

포장

Please refer to vial label for lot-specific concentration.

경고

Toxicity: Irritant (B)

물리적 형태

In PBS.

재구성

Following initial thaw, aliquot and freeze (-20°C).

분석 메모

Positive Control
HeLa cells treated with camptothecin (Cat. No. 208925)

기타 정보

Does not detect the unphosphorylated protein. Use 5% milk in TBS-T for blocking; the use of BSA is not recommended. The use of PBS-T is not recommended, as phosphate-containing buffers can contribute to high background with phosphospecific antibodies. Antibody should be titrated for optimal results in individual systems.
Horejsi, Z., et al. 2004. Oncogene23, 3122.
Abraham, R.T. 2003. Genes Dev.15, 2177.
Bakkenist, C.J. and Kastan, M.B. 2003. Nature421, 499.
Shiloh, Y. 2003. Nat. Rev. Cancer3, 155.

법적 정보

Sold under license of U.S. Patent 7,108,992.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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Scientific reports, 7(1), 4263-4263 (2017-06-29)
The B-lymphoma Moloney murine leukemia virus insertion region-1 protein (BMI1) acts as an oncogene in various cancers, including breast cancer. Recent evidence suggests that BMI1 is rapidly recruited to sites of DNA double strand breaks where it facilitates histone H2A

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