ABS442

Anti-LZTR2 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Leucine zipper-like transcription regulator 2, SEC16B, RGPR, RGPR-p117, KIAA1928, LZTR2, SEC16S, Regucalcin gene promoter region-related protein p117, Protein transport protein Sec16B, SEC16 homolog B
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: mouse
• 종 반응성(상동성에 의해 예측): human (immunogen homology)
• 기술: immunohistochemistry: suitable; western blot: suitable
• UniProt 수납 번호: Q96JE7
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SEC16B(89866)

설명

일반 설명

Leucine zipper-like transcription regulator 2 (LZTR2), also known as RGPR-p117, is a member of the SEC16 family and BTB-kelch superfamily. LZTR2 is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization. Initially, it was described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is localized in the cytoplasm but is thought to translocate to the nucleus following a hormonal stimulation and mediated by protein kinase C signaling. Recent studies has suggested that there is a strong correlation between LZTR2 and obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations. This evidence implies that LZTR2 may play an important role in metabolism and obesity risk.

면역원

KLH-conjugated linear peptide corresponding to human LZTR2.

애플리케이션

Anti-LZTR2 Antibody is a highly specific rabbit polyclonal antibody, that targets Leucine zipper-like transcription regulator 2 & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected LZTR2 in mouse kidney tissue.

Research Category
Signaling

Research Sub Category
Metabolic Hormones & Receptors

품질

Evaluated by Western Blotting in mouse kidney tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected LZTR2 in 15 µg of mouse kidney tissue lysate.

표적 설명

~92 kDa and ~140 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 3 isoforms at ~59 kDa, ~71 kDa, and ~117 kDa

물리적 형태

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Mouse kidney tissue lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable