ABS2119M

Anti-TTC39B

from rabbit

• 동의어(들): Tetratricopeptide repeat protein 39B, TPR repeat protein 39B
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 종 반응성: human, mouse
• 종 반응성(상동성에 의해 예측): rat (based on 100% sequence homology)
• 포장: antibody small pack of 25 μg
• 기술: western blot: suitable
• 동형: IgG
• NCBI 수납 번호: NP_689787
• UniProt 수납 번호: Q5VTQ0
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... TTC39B(158219)

설명

일반 설명

Tetratricopeptide repeat protein 39B (UniProt: also known as TPR repeat protein 39B, TTC39B) is encoded by the TTC39B (also known as C9orf52) gene (Gene ID: 158219) in human. TTC39B protein contains two TPR repeats (aa 393-426 and 626-659). TCC39B protein is the product of a high density lipoprotein (HDL) gene that promotes the ubiquitination and degradation of liver X receptor (LXR). TTC39B null or deficient mice challenged with high fat/cholesterol/bile salt diet exhibit increased LXR protein and target gene expression. TTC39B deficiency is reported to stabilize LXR by reducing its polyubiquitination and proteasomal degradation. Hence, it reduces the incidence of atherosclerosis and steatohepatitis. TTC39B deficient mice display higher levels of HDL and apoplipoprotein A-1 and lower levels of hepatic triglyceride synthesis. However, it does not affect glucose tolerance or hepatic gluconeogenesis. (Ref.: Hsieh, J et al. (2016). Nature 535(7611): 303-307).

특이성

This rabbit polyclonal antibody detects TTC39B in human and murine cells. It targets an epitope with in 20 amino acids from the C-terminal half.

면역원

KLH-conjugated linear peptide corresponding to 20 amino acids from the C-terminal half of human Tetratricopeptide repeat protein (TTC39B).

애플리케이션

Anti-TTC39B, Cat. No. ABS2119, is a rabbit polyclonal antibody that detects Tetratricopeptide repeat protein 39B and has been tested for use in Western Blotting.

Western Blotting Analysis: A representative lot detected TTC39B in cultured primary mouse hepatocytes transfected with T39 (Hsieh, J., et. al. (2016). Nature. 535(7611):303-7).

품질

Evaluated by Western Blotting in HEK293T cells transfected with TTC39B.

Western Blotting Analysis: 1 µg/mL of this antibody detected TTC39B in 10 µg of TTC39B transfected HEK293T cell lysate.

표적 설명

~90 kDa observed; 76.96 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

물리적 형태

Format: Purified

기타 정보

Concentration: Please refer to lot specific datasheet.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable