ABN46

Anti-DISC1 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Disrupted in schizophrenia 1 protein
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 기술: western blot: suitable
• NCBI 수납 번호: NP_001012975.1
• UniProt 수납 번호: Q9NRI5
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... DISC1(27185)

설명

일반 설명

Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.

면역원

KLH-conjugated linear peptide corresponding to human DISC1 near the N-terminus.

애플리케이션

Detect Disc1 using this rabbit polyclonal antibody, Anti-DISC1 Antibody validated for use in western blotting.

품질

Evaluated by Western Blotting in human hippocampus tissue lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected DISC1 in 10 µg of human hippocampus tissue lysate.

표적 설명

~100 kDa observed. Uncharacterized band(s) may appear in some lysates.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable